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IRCT20091213002847N4 IRCT 2023-07-22 Rafsanjan University of Medical Sciences infiltration anesthetic efficacy of 1.8 ml and 3.6 ml of articaine for mandibular incisor in irreversible pulpitis Comparation of infiltration anesthetic efficacy of 1.8 ml and 3.6 ml of articaine for mandibular incisor in irreversible pulpitis: A randomized clinical trial 2023-04-05 anticipated 90 Complete https://irct.ir/trial/70793 observational Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomizzation The even and odd numbers from 1 to 88 (even numbers for injection of 2 cartridge articaine 4% and odd numbers for injection of 1 cartridge articaine 4%) are write on separate papers and placed in the one sealed envelope, and another dentist colleague randomly takes out a number from the envelope for each patient and performs an injection based on that, Blinding description: The numbers 1 to 88 are written on cards and placed inside an envelope, where even and odd numbers each represent one of the two volumes of anesthetic drug, which is chosen by another colleague by chance, and the corresponding injection is made by him until the patient and the operator. Do not know the amount of anesthetic. N/A Pain during root canal treatment. Intervention 1: 1st Intervention group: The infiltration involved adeposition of 1.8 mL articaine (Xilonibsa, Inibsa, Barcelona, Spain) each patient received 1 cartridges of the anesthetic solution. The treatment including access cavity preparation and root canal instrumentation were performed 2-3 minutes after the injection. The patients were asked to rate their pain using a Heft-Parkervisual analog pain scale (VAS) before administration of the anesthetic solution and during the endodontic treatment. Intervention 2: 2st Intervention group: The infiltration involved adeposition of 3.6 mL articaine (Xilonibsa, Inibsa, Barcelona, Spain) each patient received 2 cartridges of the anesthetic solution. The treatment including access cavity preparation and root canal instrumentation were performed 2-3 minutes after the injection. The patients were asked to rate their pain using a Heft-Parkervisual analog pain scale (VAS) before administration of the anesthetic solution and during the endodontic treatment. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after de-identifying individuals When: The access period starts 6 months after the results are published To whom: Researchers in the fields of medical sciences Conditions: There is no limit Where to obtain: Email to Mohammad Mahdi Yaaghooti Khorasani m.yaghooti@yahoo.com How to obtain: By emailing the scientific officer and requesting to receive information, the information will be sent to the sender's email within 15 days Comments:
public Mohammad Mahdi Yaaghooti Khorasani
Imam Ali
Rafsanjan Iran (Islamic Republic of) 7717933777 +98 34 3428 0040 m.yaghooti@yahoo.com Rafsanjan University of Medical Sciences scientific Mohammad Mahdi Yaghooti Khorasani
Dental School, Shahid Mofateh Blvd.
Rafsanjan Iran (Islamic Republic of) 7717933777 +98 34 3428 0031 m_yaghooti@rums.ac.ir Rafsanjan University of Medical Sciences Iran (Islamic Republic of) Healthy patients With Mandibular Incisor teeth with irreversible pulpitis and normal Periapical Radiography Without Spontaneous pain that required Emergency treatment 18 years 60 years Both History of sensitivity to 4%articaine or epinephrine Systemic diseases Pregnancy or breastfeeding Any type of medication that could potentially interact with the anesthetic solution Spontaneous pain Periodontal disease or unable to get restoration Having analgesic late 12 hours Treatment - Drugs Treatment - Drugs 1st Intervention group: The infiltration involved adeposition of 1.8 mL articaine (Xilonibsa, Inibsa, Barcelona, Spain) each patient received 1 cartridges of the anesthetic solution. The treatment including access cavity preparation and root canal instrumentation were performed 2-3 minutes after the injection. The patients were asked to rate their pain using a Heft-Parkervisual analog pain scale (VAS) before administration of the anesthetic solution and during the endodontic treatment. 2st Intervention group: The infiltration involved adeposition of 3.6 mL articaine (Xilonibsa, Inibsa, Barcelona, Spain) each patient received 2 cartridges of the anesthetic solution. The treatment including access cavity preparation and root canal instrumentation were performed 2-3 minutes after the injection. The patients were asked to rate their pain using a Heft-Parkervisual analog pain scale (VAS) before administration of the anesthetic solution and during the endodontic treatment. Pain during root canal treatment. Timepoint: During the preparation of the access hole, entering the dentin, entering the pulp chamber or placing the file in the canal. Method of measurement: VAS. Rafsanjan University of Medical Sciences Approved 2023-03-14 Rafsanjan university of medical science Imam Ali Blvd Rafsanjan Kerman Iran (Islamic Republic of)