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IRCT20230405057822N1 IRCT 2024-01-26 Yazd University of Medical Sciences Investigating the effect of the injection speed of the combination of neostigmine and atropine on the heart rate Investigating the effect of the injection speed of the combination of neostigmine and atropine on the heart rate of patients under general anesthesia 2021-03-21 anticipated 69 Complete https://irct.ir/trial/70700 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Factorial, Purpose: Prevention, Randomization description: The studied samples were randomly divided into three groups based on the speed of reverse injection by giving sheets A, B, and C. The injection speed of the first group was 10 seconds, the second group was 1 minute, and the third group was 3 minutes, Blinding description: The researcher was not aware of the speed of the injection of neostigmine and atropine, which was done by the research colleague. Since the patient was not conscious at the time of the injection, he did not know the type of intervention. 3 the patients under going general anesthesia. Intervention 1: The first intervention group: reverse injection with a speed of 10 seconds including 3 mg of neostigmine and 1.5 mg of atropine to the first 23 patients. Intervention 2: The second intervention group: reverse injection with a speed of 1 minute including 3 mg of neostigmine and 1.5 mg of atropine to 23 second patients. Intervention 3: The third intervention group: reverse injection with a speed of 3 minutes including 3 mg of neostigmine and 1.5 mg of atropine to 23 third patients. Yes - There is a plan to make this available What will be shared: Total data When: 3 months after printing the data To whom: Anesthesiologists and experts Conditions: There are no conditions Where to obtain: To receive, contact msaleh.forghani@gmail.com How to obtain: It will be sent after the applicant's identity and documents are authenticated Comments:
public Hamid Mirhosseini
Daneshjoo
Yazd Iran (Islamic Republic of) 8916188135 +98 35 3623 8626 mirhosseini@ssu.ac.ir Yazd University of Medical Sciences scientific Hamid Mirhosseini
Daneshjoo
Yazd Iran (Islamic Republic of) 8916188135 +98 35 3623 8626 mirhosseini@ssu.ac.ir Yazd University of Medical Sciences Iran (Islamic Republic of) Hemoglobin level above 14 g/dL Anesthesia class one ASA.PS 16 years 50 years Both Patients with bleeding more than 10% blood volume Patients with a history of substance abuse and drug allergy and egg yolk allergy Having cardiac, vascular and respiratory disorders Receiving drugs that affect heart rate or central nervous system Z41.2 Encounter for routine and ritual male circumcision Treatment - Drugs Treatment - Drugs Treatment - Drugs The first intervention group: reverse injection with a speed of 10 seconds including 3 mg of neostigmine and 1.5 mg of atropine to the first 23 patients. The second intervention group: reverse injection with a speed of 1 minute including 3 mg of neostigmine and 1.5 mg of atropine to 23 second patients. The third intervention group: reverse injection with a speed of 3 minutes including 3 mg of neostigmine and 1.5 mg of atropine to 23 third patients. Pulse rate. Timepoint: 10 seconds , 1minute , 3minutes. Method of measurement: monitoring device. Yazd University of Medical Sciences Approved 2021-10-12 Ethics Committee of Shahid Sadoughi University of Medical Sciences, Yazd Imam Hossein square, at the beginning of the student boulevard, Imam Reza,research educational complex Yazd Yazd Iran (Islamic Republic of)