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IRCT201304166617N2 IRCT 2013-05-03 Isfahan University of Medical Sciences Comparison of cardiovascular response to the laryngoscopy and tracheal intubation after induction of anesthesia by propofol or etomidate Comparison of cardiovascular response to the laryngoscopy and tracheal intubation after induction of anesthesia by propofol or etomidate 2012-10-20 anticipated 50 Complete https://irct.ir/trial/7060 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A General anesthesia. Intervention 1: Propofol, 2.5 mg/kg within 30 seconds; IV. Intervention 2: Etomidate, 0.3 mg/kg within 30 seconds; IV.
public Mehrdad Masoudifar
Ayatollah Kashani hospital
Isfahan Iran (Islamic Republic of) +98 31 1233 0091 masoudifar@med.mui.ac.ir Isfahan University of Medical Sciences scientific Mehrdad Masoudifar
Isfahan university of medical sciences
Isfahan Iran (Islamic Republic of) +98 31 1233 0091 masoudifar@med.mui.ac.ir Isfahan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: being aged from 18 to 45 years old; having no underlying diseases; being of ASA 1 classification; being an applicant for elective orthopedic surgery on upper and lower extremities; not being allergic to anesthetic drugs; not having any expected problems of the airway; receiving no narcotics or sedative drugs before the anesthesia and not being hemodynamic unstablility before the anesthesia. Patients who were a 4 grade after the induction of anesthesia and laryngoscopy, or their laryngoscopy were lasted longer than 30 seconds, or were not anesthetized using the mentioned dose of drugs and received higher doses, were excluded from the study. 18 years 45 years Both T88.5 Other complications of anaesthesia Treatment - Drugs Treatment - Drugs Propofol, 2.5 mg/kg within 30 seconds; IV. Etomidate, 0.3 mg/kg within 30 seconds; IV. Systolic blood pressure. Timepoint: Before intervention, at laryngoscopy time and 1 , 3 ,5 , 10 min after drug injection. Method of measurement: mm-hg, sphygmomanometer. Diastolic bllod pressure. Timepoint: Before intervention, at laryngoscopy time and 1 , 3 ,5 , 10 min after drug injection. Method of measurement: mm-hg, sphygmomanometer. Mean arterial pressure. Timepoint: Before intervention, at laryngoscopy time and 1 , 3 ,5 , 10 min after drug injection. Method of measurement: mm-hg, sphygmomanometer. Heart rate. Timepoint: Before intervention, at laryngoscopy time and 1 , 3 ,5 , 10 min after drug injection. Method of measurement: ECG monitor. O2 saturation. Timepoint: Before intervention, at laryngoscopy time and 1 , 3 ,5 , 10 min after drug injection. Method of measurement: Pulseoxymeter. Hypotension. Timepoint: Other complications of anaesthesia. Method of measurement: mm-Hg, sphygmomanometer. Hypertension. Timepoint: Other complications of anaesthesia. Method of measurement: mm-Hg, sphygmomanometer. Tachycardia. Timepoint: Other complications of anaesthesia. Method of measurement: ECG monitor. Bradycardia. Timepoint: Before intervention, at laryngoscopy time and 1 , 3 ,5 , 10 min after drug injection. Method of measurement: ECG monitor. Isfahan University of Medical Sciences Approved 2011-11-09 Isfahan University of Medical Sciences Hezar Jarib st. Isfahan Iran (Islamic Republic of)