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IRCT20150622022869N11 IRCT 2023-06-11 Yasouj University of Medical Sciences Comparison of the effect of OABM WITH OABF regimens in In the treatment of Helicobacter pylori patients Comparison of the effect of OABM WITH OABF regimens in In the treatment of Helicobacter pylori patients 2023-06-20 anticipated 70 Complete https://irct.ir/trial/70489 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random number table method is used for randomization in this study. In this method, random table is used for randomization and patients are assigned random numbers from the table. Patients in each of the two study groups will be assigned to one of the two groups based on random numbers, Blinding description: The present study will be single blind, in which the researchers of this study will be blinded to the type of intervention assigned to the patients. 3 helicobacter pylori (h. pylori) infection. Intervention 1: First intervention group: omeprazole 20 mg twice a day (Bid) is continued for two weeks with antibiotics and then for 6 weeks without antibiotics, and after 4 weeks of this treatment period, the patient gives a stool antigen test to check the eradication of Helicobacter pylori. Amoxicillin 1 gram twice a day, bismuth citrate tablets twice a day and furazolidone 200 mg twice a day (Bid). Intervention 2: Second intervention group: omeprazole 20 mg twice a day along with antibiotics for 2 weeks and then for 6 weeks without antibiotics and alone and after this 6-week period, the patient will refer to stool antigen test method 4 weeks later without taking drugs and antibiotics for eradication test. In this group, amoxicillin one gram twice in day and two tablets of bismuth citrate twice a day (4 tablets a day) and metronidazole 500 mg twice a day. Yes - There is a plan to make this available What will be shared: The data of this study can be shared without mentioning individuals and in aggregate form after the publication of the article through administrative correspondence. When: After printing the article To whom: this is available for people working in academic institutions or people working in businesses can also apply to receive it. Conditions: Any analysis on the data will be allowed Where to obtain: m.sedaghattalab@yuma.ac.com How to obtain: After sending the email, the required data will be available for up to 1 month Comments:
public Moslem Sedaghttalab
Dr. Jalil St., campus of Yasouj University of Medical Sciences,. Yasuj
Yasuj Iran (Islamic Republic of) 7591994799 +98 74 3334 5876 m.sedaghattalab@yuma.ac.com Yasouj University of Medical Sciences scientific Moslem Sedaghttalab
Dr. Jalil St., campus of Yasouj University of Medical Sciences,. Yasuj
Yasuj Iran (Islamic Republic of) 7591994799 +98 74 3334 5876 m.sedaghattalab@yuma.ac.com Yasouj University of Medical Sciences Iran (Islamic Republic of) A patient who underwent endoscopy and has peptic ulcer disease (PUD). Patients with dyspepsia without endoscopic indication have a positive Helicobacter diagnostic test, including Helicobacter stool antigen test and.... Patients with maltoma Endoscopy patients with nud (non-ulcer dyspepsia) and patients with a history of cancer in their first degree relatives will be included in the study. Patients who have a history of pud and are Helicobacter positive and are taking NSAID Treatment-resistant dyspepsia Patient satisfaction 18 years 80 years Both Previous history of H pylori treatment Allergy to antibiotics Allergy to PPI History of gastrectomy Having gastric cancer pregnant women Taking antibiotics in the last month Taking PPI or h2blocker in the last two weeks Chronic liver, kidney or lung disease History of Fauvism B96.81 Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere Treatment - Drugs Treatment - Drugs First intervention group: omeprazole 20 mg twice a day (Bid) is continued for two weeks with antibiotics and then for 6 weeks without antibiotics, and after 4 weeks of this treatment period, the patient gives a stool antigen test to check the eradication of Helicobacter pylori. Amoxicillin 1 gram twice a day, bismuth citrate tablets twice a day and furazolidone 200 mg twice a day (Bid) Second intervention group: omeprazole 20 mg twice a day along with antibiotics for 2 weeks and then for 6 weeks without antibiotics and alone and after this 6-week period, the patient will refer to stool antigen test method 4 weeks later without taking drugs and antibiotics for eradication test. In this group, amoxicillin one gram twice in day and two tablets of bismuth citrate twice a day (4 tablets a day) and metronidazole 500 mg twice a day Frequency distribution of Helicobacter pylori antigen negativity. Timepoint: 12weeks after the start of the study. Method of measurement: Stool antigen test. Drug side effects. Timepoint: 12 weeks. Method of measurement: Clinical examination and patient presentation. Yasouj University of Medical Sciences Approved 2023-01-03 Ethics committee ofYasuj University of Medical Sciences Dr. Jalil St., campus of Yasouj University of Medical Sciences., Yasuj., Iran Yasuj Kohgilouyeh-va-Boyrahmad Iran (Islamic Republic of)