IRCT20110425006280N14 IRCT 2023-06-11 Rasht University of Medical Sciences Efficacy and safety of two muscle relaxants cisatracurium and succinylcholine in Electroconvulsive therapy Comparison of efficacy and safety of two muscle relaxants cisatracurium and succinylcholine in Electroconvulsive therapy; A randomized, single-blind clinical trial study 2023-06-22 anticipated 62 Complete https://irct.ir/trial/70281 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be divided into two groups by an anesthesia technician who does not participate in the project, using four random blocks created by the computer (Win Pepi 11.65 software). This is done through a list of eligible patients who have given informed consent. They will be assigned to one of the two groups receiving succinylcholine or cisatracurium by a sequence of randomization blocks in a 1: 1 ratio. The output of the software consists of letters and numbers. The letters A and B indicate the under-study treatments (succinylcholine and cisatracurium) and the indicated numbers indicate the patients who will be assigned to the treatments consecutively, Blinding description: This study is a single-blinded study. In this way, the patient is blind, but due to the nature of the relaxant drugs and their different pharmacodynamics, including obvious and generalized fasciculation of succinylcholine, the evaluator (resident of anesthesiology) who fills out the checklist is aware of the treatment groups. The responsible anesthesiologist present in the shock department is also aware of the groups in order to perform the necessary intervention in case of complications (bradycardia, master spasm, ECG changes in favor of hyperkalemia, hemodynamic changes, and arterial blood oxygenation). 3 Investigation of using cisatracurium instead of succinylcholine for anesthesia in electroshock therapy in cases that there is a contraindication for succinylcholine. Intervention 1: first intervention group: Before receiving anesthesia and electroshock therapy, standard monitoring of non-invasive blood pressure, pulse oximetry, electrocardiogram, and end-tidal carbon dioxide will be established and atropine 0.5 milligrams will be prescribed. After establishing a proper intravenous cateter size 20-18, induction of anesthesia with propofol 1 miligrams/kilograms and cisatracurium 0.1 miligrams/kilograms will be prescribed. Intervention 2: Second intervention group: After establishing a proper venous catheter, induction of anesthesia with propel 1 milligrams/kilograms and succinylcholine 0.5 milligrams/kilograms will be prescribed. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Not decided yet