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IRCT20221126056613N4 IRCT 2023-07-11 Oroumia University of Medical Sciences Comparison of the analgesic effect of oral Meloxicam and Diclofenac after knee arthroplasty Comparison of the analgesic effect of oral Meloxicam and Diclofenac after knee arthroplasty 2023-05-21 anticipated 128 Complete https://irct.ir/trial/70129 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be divided into two groups in a simple random manner using the numbers given by "Random Allocation" computer software. The randomization method is such that each patient is given a code and then the codes are written on a piece of paper, and after mixing the pieces of paper together, a piece of paper is randomly taken out each time and the code is related to the patient. In a list, the first 25 codes will be in the case group and the second 25 will be in the control group, Blinding description: The procedure will be performed blindly and without the knowledge of the patients and the surgeon, so the study will be double-blind. Also, with the advice of a pharmaceutics expert, the pharmaceutical forms of the two groups will be designed the same. 3 Osteoarthritis of knee. Intervention 1: Intervention group:In the intervention group, the oral form of 15 mg meloxicam will be administered. Intervention 2: Control group: In the control group, the same method will be used, but with the use of 100 mg diclofenac. Yes - There is a plan to make this available What will be shared: All data is shareable When: 1 year after the results are published To whom: It will be available only for researchers working in academic and scientific institutions b Conditions: After analyzing the data. Where to obtain: Imam Khomeini Hospital Urmia How to obtain: Refer to the Research Department of Imam Khomeini Hospital in Urmia Comments:
public Ali Akbar Nasir
Emam khomini university hospital, Eeshad AVE, Modarres Blvd, urmia, iran
Urmia Iran (Islamic Republic of) 5715781351 +98 44 3345 7286 Nasiriali7@gmail.com Oroumia University of Medical Sciences scientific Ali Akbar Nasir
Emam Khomini university hospital, Eeshad AVE, Modarres Blvd, Urmia, Iran
Urmia Iran (Islamic Republic of) 5715781351 +98 44 3345 7286 Nasiriali7@gmail.com Oroumia University of Medical Sciences Iran (Islamic Republic of) Diagnosis of knee osteoarthritis based on the scales of the American Society of Anesthesiology Candidate for knee joint replacement surgery American Society of Anesthesiology grade 1 and 2 physical status patients No history of corticosteroid or hyaluronic acid injections into the joint during the past three months No history of knee surgery or interventional treatment 18 years no limit Both Age less than 18 years pain reliever use in the past 7 days Blood and coagulation disorders Severe heart-liver and kidney failure Any absolute and relative contraindications to the use of drugs during the study Nervous disorders and the inability to accurately perceive the sensation of pain Pregnancy and breastfeeding Patients using the intravenous form of morphine M17.9 Osteoarthritis of knee, unspecified Treatment - Drugs Treatment - Drugs Intervention group:In the intervention group, the oral form of 15 mg meloxicam will be administered. Control group: In the control group, the same method will be used, but with the use of 100 mg diclofenac. Intensity of pain. Timepoint: Pain intensity will be measured at 24, 48 and 72 hours after the operation. Method of measurement: The intensity of pain after the operation of the patients will be measured using a visual analog index and scoring method from 0 (no pain) to 10 (unbearable pain). Urmia University of Medical Sciences Approved 2022-08-08 Ethics Committee in research of Imam Khomeini Medical Education Center of Urmia University of Medic Imam Khomeini Hospital, Ershad Street Urmia West Azarbaijan Iran (Islamic Republic of)