IRCT20230513058168N1 IRCT 2023-06-11 University of San Francisco Restoration of dental pulp using hydrogel Regeneration of dental pulp complex in closed apex necrotic teeth using fibrin hydrogel. 2023-05-14 anticipated 10 Complete https://irct.ir/trial/70105 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The study is designed as a Clinical trial study. The participants who meet inclusion criteria will be randomized in two groups, the experimental group receives the proposed intervention a (regenerative endodontic procedure using Fibrin hydrogel), and the control group receives conventional regeneration therapy (blood clot). The outcome will be assessed during recall examinations and after extraction, included clinical examinations, taking dental x-ray and histological tests. Selection and exclusion of subjects (experimental n:۵, control n:۵). If the root canal treatment with stem cells is successful, the teeth will be healthy like other teeth, and if the root canal treatment is not successful, the standard root canal treatment will be done free of charge, Blinding description: 10 patients are placed in two groups of 5 for study. The studied groups will include 5 people receiving the root restoration method using fibrin hydrogel, 5 people receiving standard root canal treatment. 1 teeth with with irreversible pulpitis. Intervention 1: Intervention group: Suggested root canal treatment intervention using 1 million cord stem cells in 300 microliters of fibrin hydrogel containing 300 micrograms of exosome and growth factor (NGF - VEGF) per dental canal. Intervention 2: Control group: Standard root canal treatment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.