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IRCT20130812014333N200 IRCT 2023-05-20 Kermanshah University of Medical Sciences The effect of vaginal probiotic products in eliminating Human Papillomavirus Evaluation of the effect of vaginal probiotic products in eliminating Human Papillomavirus in women with HPV 2023-06-10 anticipated 54 Complete https://irct.ir/trial/70070 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be done in a simple random method, after identifying eligible patients, they will be randomly assigned a three-digit dedicated code. The last digit on the right determines the patient group. If this number is 0, 1, 2, 3, 4, it will be assigned to the first intervention group, and if this number is 5, 6, 7, 8, 9, it will be assigned to the second intervention group. N/A human papillomavirus (HPV). Intervention 1: The intervention group will receive vaginal probiotic capsules (with the trade name Lacto vag, manufactured by the American Food and Drug Company, a pack of 30), two vaginal capsules per week for 6 months. Intervention 2: The control group will receive routine treatment. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Dr. Saba Najafi
Emam Reza Hospital, Parastar Boulevard
Kermanshah Iran (Islamic Republic of) 6715847141 +98 83 3427 6306 saba.najafi.k@gmail.com Kermanshah University of Medical Sciences scientific Dr. Maryam Zangeneh
Imam Reza Hospital, School of Medicine, parastar boulvarde
Kermanshah Iran (Islamic Republic of) 6714415153 +98 83 3426 6780 mzangeneh@kums.ac.ir Kermanshah University of Medical Sciences Iran (Islamic Republic of) Informed consent Age 21-65 years married being in the follicular period of the menstrual cycle; Not having intercourse and not washing the vagina in the last 48 hours 21 years 65 years Female Pregnant, lactating and smoking women People who are considered sick based on clinical diagnosis but whose test results are negative Using vaginal drugs such as creams, suppositories and vaginal disinfectants in the last 48 hours Suffering from certain diseases such as liver, heart, kidney disease, diabetes, central nervous system diseases, blood dyscrasias, immune system defects and known sexually transmitted diseases. Use of broad-spectrum antibiotics, antiprostaglandins, hormonal and immunosuppressive drugs, alcohol, and anticoagulant drugs during the last month B97.7 Papillomavirus as the cause of diseases classified elsewhere Treatment - Drugs Treatment - Other The intervention group will receive vaginal probiotic capsules (with the trade name Lacto vag, manufactured by the American Food and Drug Company, a pack of 30), two vaginal capsules per week for 6 months The control group will receive routine treatment Wet smear. Timepoint: 6 months after the start of the study. Method of measurement: Pap smear test. Kermanshah University of Medical Sciences Approved 2023-01-08 Ethics committee of Kermanshah University of Medical Sciences Vice Chancellor for Research Affairs, Kermanshah University of Medical Sciences, Building No.2, Shahid Beheshti Boulevard Kermanshah Kermanshah Iran (Islamic Republic of)