IRCT20150822023705N16 IRCT 2023-04-17 Kermanshah University of Medical Sciences The effectiveness of adding famotidine and vitamin B6 to standard drug treatment in patients with schizophrenia disorder Investigating the effectiveness of adding famotidine and vitamin B6 to standard drug treatment in reducing negative symptoms in patients with schizophrenia disorder: a clinical trial with a control group 2023-05-10 anticipated 80 Complete https://irct.ir/trial/69525 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be divided into two equal groups (A and B) based on a randomized size 8-block design using random allocation software. To randomly assign 80 patients to the intervention and control groups, 8 different blocks of 10 different letters A and B, which indicate Famotidine/vitamin B6 and placebo groups respectively, will be initially created. These blocks will be numbered from one to eight. In the next step, each of these blocks will be randomly selected by performing lottery using 8 cards with numbers 1 to 8 on them. Thus, in each lottery, by selecting a block, a combination of 10 letters of the letters A (Famotidine/vitamin B6 group) and B (placebo group) will be obtained. At the end of the 8 drawings, after selecting 8 blocks, a total of 80 letters A and B will be obtained. The resulting combination of letters A and B is single, and will be placed in 80 separate and sealed envelopes, respectively. Following each patient recourse, an envelope will be opened to determine the group of that patient, Blinding description: The medication and placebo are delivered to the patient without sticking the name of the medication. The doctor is also unaware of the type of drug used in each group. The color and smell of the main drug and placebo are the same. 2 Schizophrenia. Intervention 1: Intervention group: The group will receive the combination of famotidine/vitamin B6 pills in three months. The daily dose will be 1 pill of 190 mg (famotidine, 40 mg and vitamin B6, 150 mg). These pills will be given to patients without awareness of the patient and the examiner. Famotidine/vitamin B6 pills will be purchased from Caspin Daru Pharmaceutical Company. Intervention 2: Control group: The control group will receive placebo treatment in three months. Daily drug intake will be 1 pill of 190 mg. Placebo pills in terms of shape, size, color and smell are similar to the Famotidine/vitamin B6 pills. placebo will be purchased from Caspin Daru Pharmaceutical Company. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.