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IRCT20230323057764N1 IRCT 2023-05-10 Tehran University of Medical Sciences The effect of local spraying of dexamethasone in the thyroid site after thyroidectomy Investigating the effect of topical dexamethasone at the site of thyroid surgery (on the parathyroids) on blood calcium levels after surgery, compared to the control group in patients who underwent total thyroidectomy. 2023-05-22 anticipated 60 Complete https://irct.ir/trial/69300 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, the sample size is 60 people, which is less than 100. If people are divided between 2 groups by simple random method. According to the rule of randomization of taps and lines, the number of taps and lines may not be equal in two groups. Therefore, the Block-Randomization method is used. The sample size calculated in this study is 30 people in each group. Therefore, 10 blocks of 4 people are formed and 5 blocks are randomly assigned to each group. As a result, the balance between the two groups is allocated in the form of 30 people to one group and another 30 people to the second group. A simple random method is used to assign people to each block. It means that people are placed in one of these blocks based on a table of random numbers. 3 Investigating the effect of topical dexamethasone at the site of thyroid surgery (on the parathyroids). Intervention 1: Intervention group: after performing thyroidectomy in the same operating room, an ampoule of dexamethasone (8 mg-2 ml) will be sprayed at the thyroidectomy site. Intervention 2: Control group: no special action will be taken after thyroidectomy. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Seyyed Mohammad Hossein Mousavi Beyuki
Imam Khomeini Hospital Complex, at the end of Keshavarz Boulevard, Dr. Gharib Street, Tehran.
Tehran Iran (Islamic Republic of) 1419733141 +98 21 5724 8098 txhosseinmoosavi@gmail.com Iran University of Medical Sciences scientific Seyyed Mohammad Hossein Mousavi Beyuki
Imam Khomeini Hospital Complex, at the end of Keshavarz Boulevard, Dr. Gharib Street, Tehran.
Tehran Iran (Islamic Republic of) 1419733141 +98 21 5724 8098 txhosseinmoosavi@gmail.com Iran University of Medical Sciences Iran (Islamic Republic of) Patients with confirmed thyroid cancer who need total thyroidectomy Patients who do not take calcium-containing drugs Patients who do not use any corticosteroid medication Patients who had no history of thyroid or parathyroid surgery no limit no limit Both Patients who require re-operation before 48 hours due to surgical complications such as hematoma at the operation site E21.4 Other specified disorders of parathyroid gland Treatment - Drugs Treatment - Surgery Intervention group: after performing thyroidectomy in the same operating room, an ampoule of dexamethasone (8 mg-2 ml) will be sprayed at the thyroidectomy site. Control group: no special action will be taken after thyroidectomy. Blood calcium level. Timepoint: Before thyroidectomy. Method of measurement: Based on the patient's file. Blood calcium level. Timepoint: Before thyroidectomy, 6 hours, 24 hours and 48 hours after thyroidectomy. Method of measurement: Based on the patient's file. Tehran University of Medical Sciences Approved 2023-03-15 Ethics Committee of Tehran University of Medical Sciences Tehran University of Medical Sciences Headquarters, Qods Corner, Keshavarz Blvd. Tehran Tehran Iran (Islamic Republic of)