IRCT20220305054196N2 IRCT 2023-04-09 Shahid Beheshti University of Medical Sciences Investigating the effect of curcumin on the levels of liver enzymes in opium poisoning Investigating the effect of curcumin consumption on liver enzyme levels in opium-poisoned patients hospitalized in the Poisoned ICU department 2023-03-20 anticipated 30 Complete https://irct.ir/trial/69222 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, we will use the restricted randomization method of the block randomization type. The size of all the blocks is equal and we will have 6 blocks in this two-group trial, and considering 5 blocks, a total of 30 patients will be evaluated. The randomization tool will be random allocation software, Blinding description: After the selection of the samples, none of the sampled people will know about the randomization and the process of allocation to the groups, medicine and placebo are completely similar, on this basis and with the patients' lack of information about the group they are in, they have been blinded. Doctors are given a table of coded numbers in advance and patients are entered into the study in the order of the numbers in the table. Therefore, the present study is double-blind. 3 Poisoning by opium. Intervention 1: Intervention group: Curcumin supplement gavage, dose 1500 mg daily for 7 days, Dineh Pharmaceutical Company. Intervention 2: Control group: Normal saline gavage, with the rate of 1500 mg daily for 7 days, Dina Pharmaceutical Company. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information