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IRCT201408306480N7 IRCT 2014-10-03 Shahrekord University of Medical Sciences Effectiveness of vitamin B and E in reducing pain Comparing the effectiveness of vitamin B and E with diclofenac in reducing pain from osteoarthritis of the knee 2014-09-23 anticipated 120 Complete https://irct.ir/trial/6922 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Osteoarthritis of the knee. Intervention 1: Oral diclofenac 50 mg , 2 times daily and vitamin B complex tablets 2 times a day. Intervention 2: Oral diclofenac 50 mg 2 times a day, and vitamin E at a dose of 100 mg daily. Intervention 3: Oral diclofenac 50 mg 2 times a day plus a placebo pill.
public Dr Morteza Dehghan
Shahrekord University of Medical Sciences, Kashani boulevard
Shahrekord Iran (Islamic Republic of) +98 38 1333 0061 dehghan_mortaza@yahoo.com Shahrekord University of Medical Sciences scientific Doctor Morteza Dehghan
Shahrekord University of Medical Sciences, Kashani bolvard
Shahrekord Iran (Islamic Republic of) +98 38 1333 0061 dehghan_mortaza@yahoo.com Shahrekord University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria included : having 30 to 60 years of age, a diagnosis of primary osteoarthritis of the knee by an orthopedic doctor( based on history, clinical signs, physical examination, and radiographic diagnosis of the disease and diagnostic criteria related to this disease) . Exclusion criteria included : secondary osteoarthritis, infection or inflammatory disease of the knee joint, crystal-induced arthritis, tumors, intra-articular, knee ligament instability, previous fracture, intra-articular, knee surgery (arthroscopic or other in the past 12 months, an intra-articular injection, visual analog score less than 3 on the knee therapy in the treatment , severe concurrent disorders such as metabolic disorders and a history of certain diseases, including stroke in the past, uncontrolled hypertension, gastritis, infectious diseases, kidney failure, stomach ulcers, allergies to medications (vitamin B complex, vitamin E, vitamin B and E and the other contradictions receptor of vitamin E and B 30 years 60 years Both M19.9 Arthrosis, unspecified Treatment - Drugs Treatment - Drugs Placebo Oral diclofenac 50 mg , 2 times daily and vitamin B complex tablets 2 times a day Oral diclofenac 50 mg 2 times a day, and vitamin E at a dose of 100 mg daily Oral diclofenac 50 mg 2 times a day plus a placebo pill Morning stiffness. Timepoint: Intervention, two weeks and three weeks later. Method of measurement: Western Ontario MacMaster questionnaire. Pain. Timepoint: Intervention, two weeks and three weeks later. Method of measurement: Visual analog scale (VAS). Physical function. Timepoint: Intervention, two weeks and three weeks later. Method of measurement: Western Ontario MacMaster questionnaire. Consent to treatment. Timepoint: Three weeks after treatment. Method of measurement: questionnaire. Shahrekord University of Medical Sciences Approved 2013-12-15 Shahrekord University of Medical Sciences Vice Chancellor for research of Shahrekord University of Medical Sciences, Kashani Boulevard Shahrekord Iran (Islamic Republic of)