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IRCT20151228025732N76 IRCT 2023-03-10 Islamic Azad University The effect of twelve weeks of high-intensity functional training with Astaxanthin supplementation on some inflammatory markers in men with obesity The effect of twelve weeks of high-intensity functional training with Astaxanthin supplementation on some inflammatory and antioxidant markers, adipokines, myokines, and hepatokines in men with obesity 2023-03-16 anticipated 44 Complete https://irct.ir/trial/69049 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Health service research, Randomization description: We will construct 6 blocks in AABB, BBAA, ABAB, BABA, ABBA, and BAAB using four blocks. We will assign 1 to 6 for each block. Then, using the random number table, based on the sample size, 11 units of 4 blocks will be selected so that we consider having 11 people in the group (A), 11 people in the group (B), 11 people in the group (C) and 11 people in the group (D). Therefore, we will do block randomization. N/A Obesity and overweight. Intervention 1: Intervention group1: In this group, according to the protocol, they will perform a high-intensity functional training program (HIFT) in 36 sessions of 60 minutes, in which CrossFit is used. Daily exercise program: including aerobic exercise (running, jumping rope); Movements using body weight (barfix, squat) and weight lifting (front squat) are constantly changed using the CrossFit training pattern. The duration of each of the three workout programs is 20 minutes. Intervention 2: Intervention group2: In this group, according to the protocol, they will perform a high-intensity functional training program (HIFT) in 36 sessions of 60 minutes, in which CrossFit is used. and they will take 20 mg of astaxanthin capsules (Seongnam, South Korea) daily with breakfast for 12 weeks. Intervention 3: Intervention group3: In this group, according to the protocol, they will only do their daily exercises for 12 weeks and will be prohibited from participating in regular activities. and they will take 20 mg of astaxanthin capsules (Seongnam, South Korea) daily with breakfast for 12 weeks. Intervention 4: Control group: In this group, no treatment will be given and they will only do their daily exercises for 12 weeks and will be prohibited from participating in regular activities. They will receive 20 mg of raw corn starch capsules (placebo) daily with breakfast. It is only for comparison with intervention groups. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.
public Ayoub Saeidi
Islamic Azad University, Damghan branch; above Saadi square; Damghan.
Damghan Iran (Islamic Republic of) 3671637849 +98 23 3522 5045 are20935@gmail.com Islamic Azad University scientific Ayoub Saeidi
Islamic Azad University, Damghan branch; above Saadi square; Damghan.
Damghan Iran (Islamic Republic of) 3671637849 +98 23 3522 5045 are20935@gmail.com Islamic Azad University Iran (Islamic Republic of) No addiction to drugs and alcohol Not having a history of regular sports activity for at least 6 months No history of kidney, liver, cardiovascular disease and diabetes Not having any injury or physical problem Body mass index (BMI)=30 Waist-to-height ratio (WHtR)>0.5 23 years 32 years Male Any psychological disorder to the individual's own report Use of psychiatric drugs before conducting study E66 Overweight and obesity Treatment - Other Treatment - Other Treatment - Other Diagnosis Intervention group1: In this group, according to the protocol, they will perform a high-intensity functional training program (HIFT) in 36 sessions of 60 minutes, in which CrossFit is used. Daily exercise program: including aerobic exercise (running, jumping rope); Movements using body weight (barfix, squat) and weight lifting (front squat) are constantly changed using the CrossFit training pattern. The duration of each of the three workout programs is 20 minutes. Intervention group2: In this group, according to the protocol, they will perform a high-intensity functional training program (HIFT) in 36 sessions of 60 minutes, in which CrossFit is used. and they will take 20 mg of astaxanthin capsules (Seongnam, South Korea) daily with breakfast for 12 weeks. Intervention group3: In this group, according to the protocol, they will only do their daily exercises for 12 weeks and will be prohibited from participating in regular activities. and they will take 20 mg of astaxanthin capsules (Seongnam, South Korea) daily with breakfast for 12 weeks. Control group: In this group, no treatment will be given and they will only do their daily exercises for 12 weeks and will be prohibited from participating in regular activities. They will receive 20 mg of raw corn starch capsules (placebo) daily with breakfast. It is only for comparison with intervention groups. Adipokines. Timepoint: The first fasting blood sample 48 hours before and the second blood sample 48 hours after the twelve-week training period from the right arm. Method of measurement: They will be measured using laboratory kits and ELISA devices. Myokines. Timepoint: The first fasting blood sample 48 hours before and the second blood sample 48 hours after the twelve-week training period from the right arm. Method of measurement: They will be measured using laboratory kits and ELISA devices. Hepatokines. Timepoint: The first fasting blood sample 48 hours before and the second blood sample 48 hours after the twelve-week training period from the right arm. Method of measurement: They will be measured using laboratory kits and ELISA devices. Islamic Azad University Approved 2022-12-24 Ethics Committee of Islamic Azad University, Damghan branch Islamic Azad University, Damghan branch; above Saadi square; Damghan. Damghan Semnan Iran (Islamic Republic of)