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IRCT20230305057628N1 IRCT 2023-03-14 Gonabad University of Medical Sciences Association of response to doxycycline and Azithromycin antibiotics therapy with Angiotensin converting enzyme polymorphism in patients with moderate acne vulgaris Association of response to doxycycline and Azithromycin antibiotics therapy with Angiotensin converting enzyme polymorphism in patients with moderate acne vulgaris 2023-03-11 anticipated 54 Complete https://irct.ir/trial/69023 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Permuted block randomization, At first, the people who meet the criteria for entering the study will be selected based on the purpose after obtaining the consent to participate in the study, and then the people will be divided into two intervention groups in the form of block allocation. 2 Acne vulgaris. Intervention 1: Intervention group: At first, the patients are examined by a dermatologist and the severity of their acne is measured based on the Michelson acne score, and the patients are subjected to standard Photography. Next, the patients are divided into two groups. The first group receives doxycycline 100 mg daily along with topical treatment (benzoyl peroxide and tretinoin). Intervention 2: Intervention group: At first, the patients are examined by a dermatologist and the severity of their acne is measured based on the Michelson acne score, and the patients are subjected to standard Photography. Next, the patients are divided into two groups. The second group receives 250 mg of azithromycin every other day along with topical treatment (benzoyl peroxide and tretinoin). Yes - There is a plan to make this available What will be shared: All the data will be provided to the researchers without names and specifications. When: After completing the research project and publishing the article To whom: All researchers Conditions: To conduct similar research, researchers can access the results of the project by referring to the research assistant of Gonabad University of Medical Sciences with a written consent letter from the research assistant. Where to obtain: Research assistant of Gonabad University How to obtain: Researchers can have access to the results of the project by referring to the vice president of research of Gonabad University of Medical Sciences with a written consent letter from the vice president of research. Comments:
public hamide mohammadzadeh
Bohlool hospital, Parastar Blvd, Gonabad city
Gonabad Iran (Islamic Republic of) 9691797852 +98 51 5723 6832 Mohammadzadeh.hamideh@yahoo.com Gonabad University of Medical Sciences scientific hamide mohammadzadeh
Gonabad city , parastar Blvd, bohlool hospital
Gonabad Iran (Islamic Republic of) ۹۷۸۵۲_۹۶۹۱۷ +98 51 5728 6832 Mohammadzadeh.hamideh@yahoo.com Gonabad University of Medical Sciences Iran (Islamic Republic of) Acne vulgaris with moderate severity according to the MAS SCORE classification system Suffering from acne vulgaris with moderate severity according to Weishampain's classification system 12 years no limit Both L70.0 Acne vulgaris Treatment - Drugs Treatment - Drugs Intervention group: At first, the patients are examined by a dermatologist and the severity of their acne is measured based on the Michelson acne score, and the patients are subjected to standard Photography. Next, the patients are divided into two groups. The first group receives doxycycline 100 mg daily along with topical treatment (benzoyl peroxide and tretinoin). Intervention group: At first, the patients are examined by a dermatologist and the severity of their acne is measured based on the Michelson acne score, and the patients are subjected to standard Photography. Next, the patients are divided into two groups. The second group receives 250 mg of azithromycin every other day along with topical treatment (benzoyl peroxide and tretinoin). Angiotensin converting enzyme gene polymorphism. Timepoint: After the end of the treatment period. Method of measurement: PCR and electrophoresis. Response to treatment. Timepoint: Before starting the treatment, after the end of the treatment. Method of measurement: MAS score. Gonabad University of Medical Sciences Approved 2023-02-26 ethics committee of gonabad university of medical sciences House number 30, Imam Ali 2 street, gonabad city gonabad Razavi Khorasan Iran (Islamic Republic of)