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IRCT20230222057500N1 IRCT 2023-04-03 Tehran University of Medical Sciences Cell therapy with use of mesenchymal stem cells in infertile women with Thin Endometrium Cell therapy with use of mesenchymal stem cells in infertile women with Thin Endometrium 2023-04-04 anticipated 10 Complete https://irct.ir/trial/69018 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 1 Female infertility with thin endometrium. Intervention group: patients will be received three injections of Umbilical cord-derived Mesenchymal Stem Cells and their secretome.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available
public Saeedeh Torabi Goudarzi
No. 88, School of Advanced Technologies in Medicine, Italia st, Keshavarz blv.
Tehran Iran (Islamic Republic of) 1417755469 +98 21 4305 2000 s-torabig@razi.tums.ac.ir Tehran University of Medical Sciences scientific Nasim Vosoughi _ Mehdi Yousefi _ Saeedeh Torabi Goudarzi
No. 88, School of Advanced Technologies in Medicine, Italia St., Qods St., Keshavarz Blvd
Tehran Iran (Islamic Republic of) 1417755469 +98 21 4305 2000 s-torabig@razi.tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Infertile women with thin endometrium patient with thin endometrium for whom drugs and other treatments were ineffective Endometrial thickness less than 7 mm Embryo transfer is cancelled because of thin endometrium Age between 20 and 44 years HBsAg negative, HCV negative, HIV negative, CMV negative 20 years 44 years Female Abnormal karyotype Contraindications to hormone replacement therapy Systemic diseases such as hypertension, diabetes Other uterine diseases including uterine malformations, large myoma, endometrial tuberculosis, endometriosis Autoimmune diseases such as rheumatoid arthritis, lupus Unable to adhere to the follow-up N97.2 Female infertility of uterine origin Treatment - Other Intervention group: patients will be received three injections of Umbilical cord-derived Mesenchymal Stem Cells and their secretome. Endometrium thickness. Timepoint: Before the intervention and 1, 2 and 3 months after the first intervention. Method of measurement: Vaginal sonography. The effect of cell therapy on fertility rate of patients. Timepoint: 15 days after embryo transfer. Method of measurement: Using sonography and serum beta-human chorionic gonadotropin (β-hCG) level assessment by enzyme-linked immunosorbent assay (ELISA) or chemi luminescence. Tehran University of Medical Sciences Approved 2023-02-05 Research Ethics Committees of Research Institute for Oncology, Hematology and Cell Therapy - Tehran Shariati Hospital, Kargar Shomali Ave,Tehran, 14117-13135 I.R.Iran Tehran Tehran Iran (Islamic Republic of)