IRCT20230303057599N1 IRCT 2023-05-24 Tehran University of Medical Sciences effect of Agomelatin on the migraine The effectiveness of agomelatine on the severity and numbers of migraine attacks in patients with migraine 2021-09-06 anticipated 50 Complete https://irct.ir/trial/68973 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: based on random table For this random assignment method in order to create groups with the same number Half of the total number of people who are going to enter will be randomly selected from the table of random numbers. The random number between 0 and 4 get the word AB, and if it was between 5 and 9, BA is assigned to it, then according to the entry, people will be in one of the two groups - intervention or control. For example, for a sample size of 60 people, if 30 random numbers are as follows: 396147224160811382693361771706 According to the above contract: From left to right, equal to the number: 3, AB Equivalent to 9, BA Equivalent to 6, BA Equation 1: AB Equation 4: AB, Blinding description: The Medications were made by the relevant company in the same shape and design and in the same size, and only the main researcher was aware of the type of Tablets. The neurologist who prescribed, as well as the data collector and the data analyst, were unaware of which intervention the patient had undergone. 3 Migraine. Intervention 1: Intervention group: This group receives agomelatine 25 mg daily in tablet form for three months. Intervention 2: Control group: This group receives vitamin B1 tablets with the same shape and design and weight of 25 mg equivalent to agomelatine for three months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is If the journal requests, the file will be sent to them