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IRCT20190129042540N2 IRCT 2023-04-26 Rafsanjan University of Medical Sciences Effect of achillea Mellifolium in Ischemic Stroke Comparison of the effect of achillea millefolium on disability and functional state of ischemic stroke patients, A clinical trial study 2023-04-21 anticipated 110 Complete https://irct.ir/trial/68954 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Randomization was done using free web-based systems, Blinding description: Participants do not know which drug is placebo and which is the main drug. The follower of drug prescription and the examiner of the results of function and quality of life are unaware of the type of drug. 3 Ischemic stroke. Intervention 1: Treatment group: Stroke patients are randomly assigned to the treatment group. People in this group receive yarrow capsules. Capsules in a dose of 500 mg are prepared from the aqueous extract of flowering branches and yarrow leaves. First, the plant is purchased from the Isfahan herbarium after the herbarium expert confirms the species. Then it is cleaned, thoroughly washed, and dried in a cool and dark place. The capsules are extracted and prepared at Barich Essence pharmaceutical company (4 grams of plant powder is brewed in 200 ml of distilled water for 20 minutes and then the extract is separated and dried). Patients take one capsule daily, preferably with food, for 3 months. Achillea extract has anti-inflammatory and neuroprotective properties due to the presence of apigenin and luteolin and improves CNS function. So far, the effects of this medicinal plant have been studied on MS and several other inflammatory diseases , but it has not been studied on stroke. Intervention 2: Control group: Control group: The other group of cerebral ischemia stroke patients randomly use cellulose capsules made by Barij Essan company with the same shape and weight as the drug for three months. Yes - There is a plan to make this available What will be shared: All the data obtained in the study will be made available to the public after being de-identified through the writing of the article. When: The data will be published after the conclusion of the research plan and the statistical analysis of the findings and the preparation of the results in about two years. To whom: The data does not belong to specific people and the results are available to the public. Conditions: There is no special condition for using the data and the public can use the results. Where to obtain: The data will be published as an article, and if needed, it will be available through correspondence with the corresponding author's email. How to obtain: The applicant can contact the corresponding author via email and send a request for access to the results Comments:
public Alireza Vakilian
13,4th Alley, Emam Avenue
Rafsanjan Iran (Islamic Republic of) 7717937555 +98 34 3428 9393 alirezavakilian66@rums.ac.ir Rafsanjan University of Medical Sciences scientific Alireza Vakilian
13,4th Alley, Emam Avenue
Rafsanjan Iran (Islamic Republic of) 7717937555 +98 34 3428 9393 alirezavakilian66@rums.ac.ir Rafsanjan University of Medical Sciences Iran (Islamic Republic of) ischemic stroke for the first time satisfy to participate nihss less than 25 age more than 18 18 years no limit Both The use of alteplase in treatment impaired swallowing pregnancy or intend to be pregnant using other herbal medicine allergy to achillea millefolium I63 Cerebral infarction Treatment - Drugs Placebo Treatment group: Stroke patients are randomly assigned to the treatment group. People in this group receive yarrow capsules. Capsules in a dose of 500 mg are prepared from the aqueous extract of flowering branches and yarrow leaves. First, the plant is purchased from the Isfahan herbarium after the herbarium expert confirms the species. Then it is cleaned, thoroughly washed, and dried in a cool and dark place. The capsules are extracted and prepared at Barich Essence pharmaceutical company (4 grams of plant powder is brewed in 200 ml of distilled water for 20 minutes and then the extract is separated and dried). Patients take one capsule daily, preferably with food, for 3 months. Achillea extract has anti-inflammatory and neuroprotective properties due to the presence of apigenin and luteolin and improves CNS function. So far, the effects of this medicinal plant have been studied on MS and several other inflammatory diseases , but it has not been studied on stroke. Control group: Control group: The other group of cerebral ischemia stroke patients randomly use cellulose capsules made by Barij Essan company with the same shape and weight as the drug for three months. Disability scale. Timepoint: First and 3 months later. Method of measurement: Questionnaire of NIHS. Functional state. Timepoint: First and 3 months later. Method of measurement: Questionnaire of Modified Rankin Scale (mRS). Rafsanjan University of Medical Sciences Approved 2022-12-06 Rafsanjan University of Medical Sciences Ethics committee Imam Ali boulevard Rafsanjan Kerman Iran (Islamic Republic of)