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IRCT201508236420N13 IRCT 2015-11-07 Vice Chancellor for research of Shahid Sadoughi University of Medical Sciences Effect of granulocyte colony stimulating factor in ART treatment Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcome and pregnancy rates. 2015-03-21 anticipated 100 Complete https://irct.ir/trial/6870 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this trial, infertile women who were scheduled for ART and met the inclusion criteria, informed about the research design and signed a written consent form for random assignment either to case or control groups. All women were randomly divided into two groups using simple, individual through random number table. All women were consecutively assigned into two groups based on randomized list. 3 Infertility. Intervention 1: In intervention group in oocyte retrieval day, 300 microgram G-CSF ampoul infused in endometrial cavity with IUI catheter immediately after retrieval. Intervention 2: in control group (50 patients) G-CSF not infused in endometrial cavity. Yes - There is a plan to make this available What will be shared: All participant data sets are to be shared When: 2 months after the result publication To whom: Researchers working in academic institutions Conditions: use in the retrospective study Where to obtain: Yazd research and clinical center for infertility How to obtain: Request from the Research Deputy, submitted to the Research Council of the Center if the request accepts its referral to the security and after completion of the relevant forms, the request is referred to the research experts and then get the data. Comments:
public Maryam Eftekhar
Research and Clinical Center for Infertility, Bouali, Timsar Fallahy, Safayeh, Yazd
Yazd Iran (Islamic Republic of) 8916877391 +98 35 3824 7085 eftekharmaryam@yahoo.com Sadoughi University of Medical Science ,Yazd scientific Maryam Eftekhar
Research and Clinical Center for Infertility, Bouali, Timsar Fallahy, Safayeh, Yazd
Yazd Iran (Islamic Republic of) 8916877391 +98 35 3824 7085 eftekharmaryam@yahoo.com Sadoughi University of Medical Science Iran (Islamic Republic of) infertile women candidate for IVF normal endometrial thickness age18-40 years old 18 years 40 years Female repeated implantation failure endocrine disorders severe endometriosis congenital or acquired uterine anomaly renal disease sickle cell disease malignancy history upper respiratory tract infection pneumonia chronic neutropenia N98.9 Complication associated with artificial fertilization, unspecified Treatment - Drugs Treatment - Drugs In intervention group in oocyte retrieval day, 300 microgram G-CSF ampoul infused in endometrial cavity with IUI catheter immediately after retrieval. in control group (50 patients) G-CSF not infused in endometrial cavity. Chemical pregnancy. Timepoint: 14 days after embryo transfer. Method of measurement: serum βhCG. Ongoing pregnancy. Timepoint: 10 weeks after embryo transfer. Method of measurement: sonography. Abortion. Timepoint: 18 weeks after embryo transfer. Method of measurement: sonography. Clinical pregnancy. Timepoint: 3 weeks after positive BHCG. Method of measurement: sonography. Implantation. Timepoint: 3 weeks after positive BHCG. Method of measurement: assessed by the number of gestational sacs per number of transferred embryos. Vice Chancellor for research of Shahid Sadoughi University of Medical Sciences Approved 2015-02-08 Ethics committee of Shahid Sadoughi University of Medical Science Research and Clinical Center for Infertility, Bouali, Timsar Fallahy, Safayeh, Yazd Yazd Yazd Iran (Islamic Republic of)