IRCT20181219042047N2 IRCT 2023-05-01 Artesh University of Medical Sciences Effect of bromelain supplementation in head trauma patients The effect of bromelain supplementation on oxidative stress, inflammatory markers and clinical outcomes in patients with traumatic brain injury admitted to the intensive care unit of Besat hospital 2023-05-21 anticipated 58 Complete https://irct.ir/trial/68625 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are categorized and randomly assigned to the bromelain or placebo group. In order to randomly assign the patients to two groups, the classified block randomization method will be used using the website www.sealedenvelope.com. People were classified based on age (18 to 40 years and 40 to 65 years), gender (male/female) and Apache score (0 to 35 and 35 to 71) and divide into the intervention or placebo group based on blocks of four. In order to randomly allocate and based on blocks, patients who are in each of the age, gender, and APACHE II score classes, are entered into the intervention or placebo group. Randomization is concealed in sequentially numbered, sealed, opaque envelopes, Blinding description: Before starting the study, all boxes containing bromelain or placebo for double-blind implementation are coded as A and B to blind the researcher and participants. 3 traumatic brain injury. Intervention 1: Intervention group: People will receive 200 mg of bromelain 3 times a day for 14 days. Intervention 2: Control group: Subjects will receive a placebo daily for 14 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is اطلاعات بیشتری وجود ندارد