IRCT20230208057356N1 IRCT 2023-03-29 Tabriz University of Medical Sciences The effect of using probiotics along with orthodontic wax on the pain and ulcers relief in patients undergoing fixed orthodontic treatment The effect of using probiotics along with orthodontic wax on the pain and ulcers relief in patients undergoing fixed orthodontic treatment 2023-02-28 anticipated 28 Complete https://irct.ir/trial/68556 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Stratified randomization based on sex. People are randomly placed in one of the two study groups with the help of a random number table and receive the intervention related to the same group. In order to hide the random allocation, the method of sealed opaque envelopes with a random sequence (envelopes opaque, sealed, numbered sequentially) will be used. In this method, each of the generated random sequences is recorded on a card and The cards are placed in the letter envelopes in order. Finally, the lid of the letter envelopes is glued and placed in a box. At the time of starting the registration of participants, based on the order of entry of eligible participants into the study, one of the envelopes will be opened and the assigned group of that participant will be revealed, Blinding description: Only the person examining the teeth will be blinded and will examine the teeth before and after the intervention without knowing which group the patient was in. The patient or his legal guardian will not be blinded because the type of intervention is visible and recognizable. Of course, patients will be assigned to random groups. 2-3 بیمار دارای مال اوکلوژن. Intervention group: These patients receive orthodontic waxes and it is explained to them that if the components of the orthodontic device cause a wound in the oral tissue, they should soften the wax in their hand and place it on the part that caused the wound and until the wound heals. Renew the wax. In addition to wax, this group will receive Lactogam probiotic lozenges from the beginning of the treatment, and the method of using these lozenges will be once a day for 4 weeks after using a toothbrush and dental floss. The lozenge is placed in the mouth and given enough time to dissolve completely in the mouth. Patients will be taught to stop taking probiotics if they develop symptoms of allergy.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.