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IRCT20230211057389N1 IRCT 2023-12-10 Karaj University of Medical Sciences Efficacy of Gemfibrozil as an adjust therapy in obsessive compulsive disorder, a randomized clinical trial with medication control OCD Efficacy of Gemfibrozil as an adjusted therapy in obsessive-compulsive disorder in patients with obsessive-compulsive disorder 2023-12-22 anticipated 40 Complete https://irct.ir/trial/68525 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Factorial, Purpose: Treatment, Randomization description: The block randomization method with unequal block sizes will be used to allocate the samples to one of the two intervention groups and the comparison group. The randomization list will be prepared in advance using web software with an electronic address, and the researcher who is not involved in the patient selection and allocation process will have access to this form. The size of the blocks will be 2-4 and 6 {https://www.sealedenvelope.com/simple-randomiser/v1/lists}, Blinding description: In this research, blinding will be done for the patients participating in the study as well as the researcher evaluating the outcome and the researcher analyzing the data. For blinding, patients will be divided into two groups, A and B, and the randomization list will be prepared in advance with https://www.sealedenvelope.com/simple-randomiser/v1/lists using web software with an email address. Only the researcher who is not involved in the patient selection and allocation process will have access to this form. The size of the blocks will be 2, 4, and 6. 3 Obsessives-Compulsive disorder. Intervention 1: Intervention group: The intervention group (20 people) will receive Gemfibrozil (300 mg per day) and Sertraline (100 mg per day) for 8 weeks. Intervention 2: Control group: (20 people) will receive sertraline (100 mg per day) for eight weeks. Yes - There is a plan to make this available What will be shared: The whole study data will be published after respecting the confidentiality of the patient's information. When: 3 months after printing the results To whom: Researchers in the field of psychiatry Conditions: Respecting the privacy of patients' information Where to obtain: Siavash Kianmehr, a student of general medicine Email: Kianmehrsiavash@gmail.com Contact number: 09124611536 How to obtain: A written request via email to the author of the article, which will be answered within two weeks. Comments:
public Siavash Kianmehr
Karaj Shahin Villa Shahrak Ibn Sina Agricultural Bank 13th Kian Building Unit 3
Karaj Iran (Islamic Republic of) 3193747528 +98 912 461 1536 Kianmehrsiavash@gmail.com Karaj University of Medical Sciences scientific Siavash Kianmehr
Karaj Shahin Villa Shahrak Ibn Sina Agricultural Bank 13th Kian Building Unit 3
Karaj Iran (Islamic Republic of) 3193747528 +98 912 461 1536 Kianmehrsiavash@gmail.com Karaj University of Medical Sciences Iran (Islamic Republic of) Having DSM-V diagnostic criteria for obsessive-compulsive disorder ages between 18 to 60 18 years 60 years Both Abuse of drugs and medicine except nicotine and caffeine Known case of Mental Retardation Presence of other mental disorders The presence of psychotic manifestations Presence of significant medical or neurological disease (advanced kidney disease, CKD, liver disease, cardiovascular disease, and hypertension) and history of gallstones Concomitant use of warfarin Concomitant use of insulin Concomitant use of Statin group Concomitant use of niacin group drugs F60.5 Obsessive-compulsive personality disorder Treatment - Drugs Treatment - Drugs Intervention group: The intervention group (20 people) will receive Gemfibrozil (300 mg per day) and Sertraline (100 mg per day) for 8 weeks. Control group: (20 people) will receive sertraline (100 mg per day) for eight weeks Score of Yale-Brown Obsessive-Compulsive scale. Timepoint: Second, fourth and eighth week. Method of measurement: Yale-Brown Obsessive-Compulsive scale. Alborz University of Medical Science Approved 2023-10-21 Ethics committee of Alborz University of Medical Science Karaj Shahin Villa Shahrak Ibn Sina Agricultural Bank 13th Kian Building Unit 3 کرج Alborz Iran (Islamic Republic of)