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IRCT20221211056777N3 IRCT 2023-08-18 Shahre-kord University of Medical Sciences Investigating the effect of curcumin capsules on cisplatin-induced kidney damage Evaluation the Effect of Curcumin Capsules on Prevention of Nephropathy Caused by Chemotherapy with Cisplatin( double blind clinical trial) 2023-05-22 anticipated 50 Complete https://irct.ir/trial/68514 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: 50 cancer patients referring to Hajar Shahrekord Hospital are divided into two groups of 25 each by the permutation block randomization method with a size of 10. The randomization list will be prepared by random allocation software and people will be assigned to groups named A and B, Blinding description: This study will be conducted in a double-blind manner. The objectives of the study will be explained to the participants. In order to blind the patients, curcumin and placebo capsules will be prepared from the same company in similar packaging. The participants will not know which intervention group they are in. Also, the researcher is not aware of the contents of the medicine package. 3 cancer. Intervention 1: Intervention group: Cancer patients treated with cisplatin who will receive 80 mg curcumin capsules (Sina Curcumin Company) 2 times a day for 9 weeks. Intervention 2: Control group: Cancer patients treated with cisplatin who will placebo capsules (Sina Curcumin Company) 2 times a day for 9 weeks. Yes - There is a plan to make this available What will be shared: To share the data and documents of this research, only the information related to the main outcome will be shared. Also, files that can be published and do not violate people's privacy will be published. When: The access period will start 6 months after the results are published. To whom: Our data will only be available to researchers working in academic and scientific institutions Conditions: Except for personal information about people, all of our data will be shared if certain requirements are met. Our data will only be used for comparable study and peer review by other researchers. Anyone working in universities or scientific institutions who wants to do similar study or confirm the accuracy of our data can access our data. Where to obtain: All qualified individuals can collect data by referring to the project manager in order to acquire information. Contact information is available via email at shimarahmati1987@gmail.com or the contact number 00989139854865 How to obtain: To receive information after sending the request, the requests will be reviewed within 10 days. If the above conditions are met, the information will be sent to the provided email within 30 days at most. Comments:
public Shima Rahmati
Kashani Street, Shahrekord, Chaharmahal va Bakhtiary, Iran
Shahrekord Iran (Islamic Republic of) 8816754633 +98 38 3222 0016 shimarahmati1987@gmail.com Shahre-kord University of Medical Sciences scientific Kiavash Fekri
Kashani Street, Shahrekord, Chaharmahal va Bakhtiary, Iran
Shahrekord Iran (Islamic Republic of) 8816754633 0383222116 k.fekri@skums.ac.ir Shahre-kord University of Medical Sciences Iran (Islamic Republic of) Cancer patients over 5 years of age who are being treated with cisplatin be the same in terms of medications and supplements taken Absence of kidney tumor No kidney failure 5 years no limit Both Diagnosing the presence of kidney stones in patients Patient non-cooperation Treatment - Drugs Placebo Intervention group: Cancer patients treated with cisplatin who will receive 80 mg curcumin capsules (Sina Curcumin Company) 2 times a day for 9 weeks. Control group: Cancer patients treated with cisplatin who will placebo capsules (Sina Curcumin Company) 2 times a day for 9 weeks. Serum levels of sodium. Timepoint: before the intervention and 8 weeks after the intervention. Method of measurement: Measurement of serum sodium level with a Flame Photometer. Serum levels of potassium. Timepoint: before the intervention and 8 weeks after the intervention. Method of measurement: Measurement of serum potassium level with a Flame Photometer. Serum levels of calcium. Timepoint: before the intervention and 8 weeks after the intervention. Method of measurement: Measurement of serum calcium level with a Flame Photometer. Serum levels of magnesium. Timepoint: before the intervention and 8 weeks after the intervention. Method of measurement: Measurement of serum magnesium level with a Flame Photometer. Serum levels of creatinine. Timepoint: before the intervention and 8 weeks after the intervention. Method of measurement: Measurement of serum creatinine level with a Flame Photometer creatinine. Serum levels of blood urea nitrogen. Timepoint: before the intervention and 8 weeks after the intervention. Method of measurement: Measurement of serum blood urea nitrogen level with a Flame Photometer creatinine. A quantitative measure of GFR. Timepoint: before the intervention and 8 weeks after the intervention. Method of measurement: Absolute measurement of glomerular filtration rate (GFR) according to creatinine clearance formula (GFR=Ucr*v/Pcr*1440). Shahre-kord University of Medical Sciences Approved 2022-07-27 Ethics Committee of the School of Medicine, Shahrekord University of Medical Sciences Headquarters of Shahrekord University of Medical Sciences,Kashani Street, Shahrekord, Chaharmahal va Bakhtiary, Iran Shahrekord Chahar-Mahal-va-Bakhtiari Iran (Islamic Republic of)