IRCT20130418013058N16 IRCT 2023-04-24 Mashhad University of Medical Sciences Evaluation of crocin in patients with refractory focal epilepsy Evaluation of the effectiveness of crocin as a supplement in patients with refractory focal epilepsy in a randomized double-blind clinical trial 2023-04-30 anticipated 40 Complete https://irct.ir/trial/68448 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: For each tablet container, four-digit codes will be Randomly labeled to Each Box by pharmacist . The Therapist will give it to the Patient Randomly without Knowledge of the Type of Medicine. Thus, the nature of each code will not be known until the analysis of the results, Blinding description: Crocin and placebo tablets will be prepared in a similar shape, color, and size, stored in a dark container and coded by a pharmacist. The physician, researcher and patients will not be aware of the code printed on the container. 2-3 Focal epilepsy disease. Intervention 1: Intervention group: receiving crocin, who received two 15 mg crocin tablets daily for three months. Intervention 2: Control group: Placebo recipients (placebo), who receive two placebo pills daily for three months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After the project, the information will be published in the form of an article.