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IRCT20220317054318N3 IRCT 2023-02-09 Hamedan University of Medical Sciences The effect of PRP in the treatment of ezoospermia Evaluate the effect of platelet-rich plasma(PRP) by testicular injection on spermogram parameters of infertile men with Non-obstructive Azoospermia candidate for TESE 2023-02-20 anticipated 68 Complete https://irct.ir/trial/68440 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Other, Purpose: Treatment, Randomization description: The first stage of selection of those eligible to enter the study is done in an easy and accessible way, but after selecting those eligible to enter the study, the participants are randomly divided into two intervention and control groups. Randomization is done by block method and considering that we have two groups, blocks of 4 are used. Blocked randomization is for the purpose of making sure that exactly the same number of participants enter the 2 control intervention groups in consecutive but equal time intervals. For this purpose, random block is used. 18 sheets of paper are prepared and the letter A is written on 9 sheets and the letter B is written on the other 9 sheets. and upon the application of each eligible person to enter the study, one of the sheets is randomly drawn and assigned to the intervention and control group based on whether it is group A or B, and the drawn sheets until all 18 sheets If it has not been pulled out, it will not be returned to the drawer, and after randomly pulling out all 18 sheets, all the sheets are returned to the drawer and the above procedure is continued on the next 18 patients up to 4 times, i.e. completing the sample volume to 68, Blinding description: Participants are blinded to the treatment method during the study. 0 (exploratory trials) Azoospermia. Intervention 1: Intervention group:34 patients who were once injected with 2 cc of platelet-rich plasma inside the testicular tissue by a regular urologist. Intervention 2: Control group: 34 patients for whom placebo is used. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public SHamim Pilehvary
Pasdaran Street
Hamedan Iran (Islamic Republic of) 6517789971 +98 81 3834 0266 sh.pilevar@umsha.ac.ir Hamedan University of Medical Sciences scientific SHamim Pilehvary
Pasdaran Street
Hamedan Iran (Islamic Republic of) 6517789971 +98 81 3834 0266 Sh.pilevar@umsha.ac.ir Hamedan University of Medical Sciences Iran (Islamic Republic of) Age range 20-45 years Having no sperm in 2 sperm analysis samples 20 years 45 years Male Receive other treatments Suffering from underlying diseases (such as diabetes, kidney disease, liver disease, drug and alcohol use) and types of cancer and receiving chemotherapy treatments Addiction and use of cigarettes N46 Male infertility Treatment - Surgery Other Intervention group:34 patients who were once injected with 2 cc of platelet-rich plasma inside the testicular tissue by a regular urologist. Control group: 34 patients for whom placebo is used. Number, movement and shape of sperm. Timepoint: 3 month. Method of measurement: Sperm analysis. Hamedan University of Medical Sciences Approved 2023-01-28 Ethics Committee of Hamadan University of Medical Sciences Pasdaran Street Hamedan Hamadan Iran (Islamic Republic of)