IRCT20210611051539N3 IRCT 2023-03-05 Mazandaran University of Medical Sciences Evaluation of the effect of Nano zataria multiflra antifungal supplement on patients with onychomycosis with saprophytic agent evaluation of antifungal supplement properties of zataria multiflora - loaded nanostructural lipid carriers in the treatment of onychomycosis caused by filamentous fungi 2023-02-19 anticipated 30 Complete https://irct.ir/trial/68406 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In that study, nano thyme gel and placebo were prepared in completely similar packaging and drug tubes, and in order to observe random allocation, www.randomizer.org was used in such a way that by using the codes received from the site, the drug and The isolated placebo is then placed inside a similar envelope and presented to the patient in a completely random manner. Therefore, the patient will not be informed about the nature of the drug and the type of group it belongs to. Since the smell created by Shirazi thyme essential oil can cause deviations in the study, therefore, both the drug and the placebo are mixed together in a closed tube and the doctor or expert randomly gives the drug to the patient. Gives, Blinding description: The patients participating in the study, as well as the researcher, including the master student who is responsible for their dissertation, as well as the physicians who perform the intervention, are among the people who are blinded in the study. The drug and placebo are both placed in similar envelopes. The fellow doctors and graduate students who are performing the intervention are not aware of its contents. Only the drug code and the patient code will be stated in the questionnaire. But the executor is aware of the code as an analyst and assigns it to control and intervention groups. Participants, on the other hand, are not aware of the contents of the envelope, but will be informed that their supplement may be a placebo. 2-3 onychomycosis. Intervention 1: Intervention group: Intervention group: For patients with onychomycosis caused by filamentous fungi, 1% nano thyme gel made in Mazandaran University of Medical Sciences in 60 gram tubes is used twice a day for 1 month. Auxiliary medicine is taken along with the main medicine that is determined by a specialist doctor. Intervention 2: Control group: For patients with onychomycosis caused by filamentous fungi, a placebo gel made in Mazandaran University of Medical Sciences in 60 gram tubes is used twice a day for 1 month. It is consumed by a specialist doctor. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I will share after the implementation and completion of the project and also after the publication of the article