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IRCT20230104057046N1 IRCT 2023-03-12 Gorgan University of Medical Sciences Investigating the effect of combined mouthwash of chlorhexidine, benzydamine, nanosilver and antibiotics in perichronitis patients Investigating the effect of combined mouthwash of chlorhexidine, benzydamine, nanosilver and antibiotics in improving the amount of pain and maximum opening of the mouth of perichronitis patients: a randomized controlled clinical trial 2023-02-20 anticipated 58 Complete https://irct.ir/trial/68000 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In the Excel software, we enter 29 items A and 29 items B in one column. In the opposite column, we generate random numbers using the rand() command, and sorting from small to large can be done based on the second column. One of the implementation plans that evaluates the messages does not give, it pastes the web letters that only it knows about which one it is related to and which of the drugs it knows on the drug drug and the drug listed in Excel is in order . It will be allocated to referring patients, Blinding description: Participants and experimenters were blinded (double-blind). The bottles containing medicine are the same for both the control and intervention groups, and the intervention and control groups are divided into two groups, A and B, but the experimenter has no knowledge of these two groups, and the participants of the experiment have no knowledge of the type and group of the case. They don't have a test. The data analyst also has no knowledge of the tested group. 3 pericoronitis. Intervention 1: Intervention group: The intervention group is provided with a combined mouthwash containing chlorhexidine, benzydamine, nanosilver and antibiotics amoxicillin and metronidazole. Each study subject receives a 280 ml bottle containing mouthwash. Use 20 ml of mouthwash for 7 days. The mouthwashes are made by a pharmacist who is a consultant in the project. Intervention 2: Control group: The control group will be given mouthwash containing 0.12% chlorhexidine. Each study subject will receive a 280 ml bottle containing mouthwash, each patient will be taught to use 20 ml each time for 7 days Use mouthwash daily. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Neman Arekhi
Ata abad village, farhang Ave
Aqqalla Iran (Islamic Republic of) 4938136953 +98 17 3450 2115 dr.mortazavi@webmail.goums.ac.ir Gorgan University of Medical Sciences scientific Neman Arekhi
Ata abad village, farhang Ave
Aqqalla Iran (Islamic Republic of) 4938136953 +98 17 3450 2115 dr.mortazavi@webmail.goums.ac.ir Gorgan University of Medical Sciences Iran (Islamic Republic of) Acute perichronitis The need to be available during the research process Having informed consent no limit no limit Both presence of chronic systemic disease (diabetes, kidney disease) receiving systemic or local antibiotic therapy in the last 3 months chronic perichronitis symptoms of severe perichronitis such as fever (<38.3°C) and facial swelling Periodontal disease in the area of ​​perichronitis Smoking Alcohol consumption Pregnancy and breastfeeding Allergy to amoxicillin or non-steroidal anti-inflammatory drugs Treatment - Drugs Placebo Intervention group: The intervention group is provided with a combined mouthwash containing chlorhexidine, benzydamine, nanosilver and antibiotics amoxicillin and metronidazole. Each study subject receives a 280 ml bottle containing mouthwash. Use 20 ml of mouthwash for 7 days. The mouthwashes are made by a pharmacist who is a consultant in the project. Control group: The control group will be given mouthwash containing 0.12% chlorhexidine. Each study subject will receive a 280 ml bottle containing mouthwash, each patient will be taught to use 20 ml each time for 7 days Use mouthwash daily. Pain. Timepoint: Examining the amount of pain before using mouthwash and on days 1, 2, 3, 4, 5, 6 and 7 after using combined mouthwash compared to chlorhexidine mouthwash in perichronitis patients. Method of measurement: The amount of pain will be measured according to the standard VAS scale on a 100 mm chart. "Maximum mouth opening of pericroniitis patients". Timepoint: Investigating the amount of maximum mouth opening before using mouthwash and on days 1, 2, 3, 4, 5, 6 and 7 after using combined mouthwash compared to chlorhexidine mouthwash in perichronitis patients. Method of measurement: The maximum amount of mouth opening by a graduated ruler. Gorgan University of Medical Sciences Approved 2022-04-20 Ethics Committee of Golestan University of Medical Sciences Agh Qola city, Ataabad village, Farhang street, Farhang first alley Gorgan Golestan Iran (Islamic Republic of)