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IRCT20200825048515N63 IRCT 2023-01-17 Esfahan University of Medical Sciences The effect of fenofibrate for seizure control in epilepsy patients Investigating the effect of fenofibrate for seizure control in refractory epilepsy patients 2023-02-19 anticipated 30 Complete https://irct.ir/trial/67921 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment, Randomization description: In this study, 30 eligible patients will be selected randomly and all will undergo a specific treatment. The present study does not have a control group, Blinding description: In this study, fenofibrate drug is prepared and provided to the researcher, and he prescribes it without knowing the type of drug. Also, the person recording the patient's clinical information and the statistical analyst will not be aware of the type of intervention. 2 Refractory epilepsy. Intervention group: In this group, the dosage of fenofibrate drug starts with 100 mg daily, and if the seizures are not controlled, it is increased to 200 mg per day after two weeks.. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information.
public Mohammad Reza Najafi
Neurology Department, Al-Zahra Hospital, Hezar Jarib Street
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 Najafi@med.mui.ac.ir Esfahan University of Medical Sciences scientific Mohammad Reza Najafi
Neurology Department, Al-Zahra Hospital, Hezar Jarib Street
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 Najafi@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Epilepsy patients Age more than 18 years Resistant to at least two anticonvulsants Having seizures on average twice a month or more Consent to participate in the study 18 years no limit Both Concurrent liver and kidney disease and hyperlipidemia Atorvastatin drug use G40.91 Epilepsy, unspecified, intractable Treatment - Drugs Intervention group: In this group, the dosage of fenofibrate drug starts with 100 mg daily, and if the seizures are not controlled, it is increased to 200 mg per day after two weeks. Number of seizure attacks. Timepoint: Before and after the intervention. Method of measurement: Seizure attack frequency. EEG changes. Timepoint: Before and after the intervention. Method of measurement: Electrocardiogram (ECG). Isfahan University of Medical Sciences Approved 2022-09-07 Ethics committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Hezar Jarib Street, Azadi Square Isfahan Isfehan Iran (Islamic Republic of)