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IRCT20230102057018N1 IRCT 2023-04-24 Research Assistant of Tabriz University of Medical Sciences Effect of morphin in prognose of Anterior MI Evaluation of the effect of morphine administration on serum CKMB level, ST segment depression and TIMI effect in patients with first acute anterior myocardial infarction who underwent primary coronary angioplasty. 2023-03-21 anticipated 200 Complete https://irct.ir/trial/67912 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Health service research, Other design features: In this study, the dose of morphine received was different compared to similar studies, and also three cases of TIMI FLOW, ST and CKMB levels will be evaluated together for the first time, Randomization description: Restricted randomization(Random allocation rule)/Random allocation software(SAS)/In order to hide, the method of Numbered drug containers will be used, Blinding description: - Apart from knowing the type of study and participation in the study and possible complications, the participant is completely blinded to which group he is in and what the results of the data are like. - The health personnel have no knowledge of the type and process of the study and only follow the orders - Those responsible for data collection and those who evaluate the outcome are completely blinded to the study process. 3 Acute Anterior ST Elevatiom Myocardial Infarction. Intervention 1: Intervention group: For this group, morphine sulfate is injected in the lab coat and on the angiography bed with a dose of 1 mg intracoronary and 3 mg intravenous. 3 mg of intravenous morphine diluted with 5 cc of distilled water and 1 mg of intracoronary morphine diluted with 5 cc of distilled water and injected only once at the beginning of angioplasty in the doses described. 90 minutes after angioplasty, an electrocardiogram was taken in ccu and compared with the initial tape in terms of ST segment loss. During admission to the ccu and at an interval of 8 hours, blood is taken from the patient up to 3 times and sent to the laboratory to evaluate the level of ckmb. The angiography films are given a TIMI FLOW score according to the final TIMI flow. Intervention 2: Control group: Control group: This group does not receive any morphine and on the angiography bed, only 5 cc of distilled water is injected intracoronary and 5 cc of distilled water intravenously. 90 minutes after angioplasty in the ccu, an ECG is taken from the patients and it is compared with the initial tape in terms of ST segment loss. When entering the ccu and at an interval of 8 hours, the patient's blood is taken 3 times and sent to the laboratory to evaluate the ckmb level. The angiography films will be awarded according to the final TIMI flow by the project manager and the points corresponding to TIMI FLOW will be awarded to them. The implementation of the plan is evaluated and reviewed. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Parviz Shahaby
Azadi St., Golbad St., University Quay, Tabriz university of medical sience
Tbriz Iran (Islamic Republic of) 5166615573 009841333900 Tohidyahyapoor1382@gmail.com Research Assistant of Tabriz University of Medical Sciences scientific Parviz Shahaby
Azadi St., Golbad St., University Quay,Tabriz university of medical sience
Tabriz Iran (Islamic Republic of) 5166615573 009841333739003 Tohidyahyapoor1382@gmail.com Research Assistant of Tabriz University of Medical Sciences Iran (Islamic Republic of) Typical cardiac chest pain lasting at least 20 minutes ST segment elevation of at least 1 mm repeated in two consecutive leads Q wave not seen with ST segment elevation patient's first acute anterior myocardial infarction A heart attack has occurred in the last 6 hours initial TIMI score is 0 or 1 no morphine injection in the emergency room or before no limit no limit Both receiving fibrinolytic receiving cardiac electric shock resuscitating the patient being intubated having VT or VF arrhythmia history of CABG complete heart block respiratory failure history of liver cirrhosis early TIMI flow 2 or more I21.0 ST elevation (STEMI) myocardial infarction of anterior wall Treatment - Drugs Treatment - Drugs Intervention group: For this group, morphine sulfate is injected in the lab coat and on the angiography bed with a dose of 1 mg intracoronary and 3 mg intravenous. 3 mg of intravenous morphine diluted with 5 cc of distilled water and 1 mg of intracoronary morphine diluted with 5 cc of distilled water and injected only once at the beginning of angioplasty in the doses described. 90 minutes after angioplasty, an electrocardiogram was taken in ccu and compared with the initial tape in terms of ST segment loss. During admission to the ccu and at an interval of 8 hours, blood is taken from the patient up to 3 times and sent to the laboratory to evaluate the level of ckmb. The angiography films are given a TIMI FLOW score according to the final TIMI flow. Control group: Control group: This group does not receive any morphine and on the angiography bed, only 5 cc of distilled water is injected intracoronary and 5 cc of distilled water intravenously. 90 minutes after angioplasty in the ccu, an ECG is taken from the patients and it is compared with the initial tape in terms of ST segment loss. When entering the ccu and at an interval of 8 hours, the patient's blood is taken 3 times and sent to the laboratory to evaluate the ckmb level. The angiography films will be awarded according to the final TIMI flow by the project manager and the points corresponding to TIMI FLOW will be awarded to them. The implementation of the plan is evaluated and reviewed. Coronary timi flow. Timepoint: in angiographic last view. Method of measurement: According to the international definition of coronary Timi Flow. The degree of ST segment depression in the patient's ECG. Timepoint: 90 minutes after the patient enters the CCU. Method of measurement: Obtaining an ECG by the patient's nurse and reading it by a cardiologist. Research Assistant of Tabriz University of Medical Sciences Approved 2022-12-05 Research Ethics Committee of Tabriz University of Medical Sciences Azadi St., Golbad St., University St. Tabriz East Azarbaijan Iran (Islamic Republic of)