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IRCT20221227056937N1 IRCT 2023-01-12 Shahid Beheshti University of Medical Sciences Investigating the effect of liquid PRF in maintaining dental socket The Comparison of clinical, radiographic and histological outcomes of socket preservation following tooth extraction using allograft with and without injectable platelet rich fibrin 2022-11-22 anticipated 15 Complete https://irct.ir/trial/67830 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: Not informing the patient about the exact type of possible practical measures for each group (of course, after giving the necessary explanations and clarifying the issue and obtaining an informed consent) and not knowing the outcome finder about the type of therapeutic intervention performed. N/A Maintaining the socket dimensions of the tooth after tooth extraction for implant treatment. Intervention 1: Control group: Allograft group without I-PRF substance.the socket is filled with allograft material (Itp Regen) and covered with collacone. Then, a cross stitch (figure of eight) will be applied with a 4-0 vicryl absorbable thread. Intervention 2: Intervention group: Allograft group plus I-PRF. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is In this regard, the necessary arrangements have not yet been made and access to the supervisor will not be possible for some time due to special reasons
public masoud Hatami
No. 9, Unit 4, Sobakro Karimi Alley, North Eskandari St.
Tehran Iran (Islamic Republic of) 1419764675 +98 21 6694 0647 Hatamimassod@yahoo.com Shahid Beheshti University of Medical Sciences scientific Masoud Hatami
Azadi street ,North Eskandari street,Sabokro Karimi alley,block 9
Tehran Iran (Islamic Republic of) 1419764675 +98 21 6694 0647 Hatamimassod@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) The patient must be over 18 years old single root tooth that needs to be pulled and replaced with dental implant restoration. Remaining bone support more than 50% 18 years no limit Both The presence of any systemic disease or disease that affects bone healing Taking any medicine that is effective on bone healing Existence of severe or uncontrolled systemic disease Pregnancy Daily consumption of 10 cigarettes or more History of radiotherapy Having a contraindication for implant placement Using any prosthesis in the intervention site Need for antibiotic prophylaxis Presence of widespread infection near the intervention site Treatment - Surgery Treatment - Surgery Control group: Allograft group without I-PRF substance.the socket is filled with allograft material (Itp Regen) and covered with collacone. Then, a cross stitch (figure of eight) will be applied with a 4-0 vicryl absorbable thread Intervention group: Allograft group plus I-PRF Alveolar socket width: the width of the alveolar bone in the midbuccal region from the buccal side to the lingual side of the drawn tooth. Timepoint: At the beginning of the study (before the start of the intervention) and 3 months after the intended treatment. Method of measurement: The digital caliper calculates the width of the alveolar bone in the midbuccal area from the buccal to the lingual side of the extracted tooth with an accuracy of 0.01 mm. Radiographic evaluation. Timepoint: The beginning of the study (before the intervention) and 3 months after the intervention. Method of measurement: By using CBCT deviceThe alveolar socket is evaluated in the buccolingual and mesiodistal dimensions at 1, 3 and 5 mm sections. Amount of vital bone. Timepoint: At the beginning of the study (before the start of the intervention) and 3 months after the intervention. Method of measurement: Presence of osteocyte and osteoblast along with bone trabeculae in bone tissue through light microscope evaluation. Socket vertical height in the midbuccal region. Timepoint: At the beginning of the study (before the start of the intervention) and 3 months after the intervention. Method of measurement: The height of the alveolar bone in the midbuccal area from the CEJ of the adjacent tooth to the edge of the alvelar crest was measured with a digital calliper to the accuracy of 0.01 mm. Shahid Beheshti University of Medical Sciences Approved 2022-11-14 Ethics Committee of Shahid Beheshti University of Medical Sciences, Tehran Shahid Chamran Highway-Yemen St.-Daneshjo Blvd.- Shahid Beheshti Faculty of Dentistry, Tehran Tehran Tehran Iran (Islamic Republic of)