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IRCT20200127046282N26 IRCT 2023-04-21 Tehran University of Medical Sciences Comparison of the safety and effectiveness of local spray stem cells conditioned medium and erbium laser compared to triamcinolone and erbium laser in the treatment of hand eczema Comparison of the safety and effectiveness of Wharton jelly mesenchymal stem cell condition medium spray and erbium laser with triamcinolone and erbium laser in the treatment of resistant hand eczema 2023-05-05 anticipated 20 Complete https://irct.ir/trial/67651 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Considering that the number of cases in this research plan is 20 people, which should be randomly divided into two groups of 10 people, therefore, the randomization method in this research plan will be done in such a way that the patients will be randomly selected using the systematic randomization method and the resulting numbers. From the computer, they will be divided into two groups of 10 people, Blinding description: The patients and the data analyst will not know the type of treatment, so the study will be conducted in a double-blind manner. 1 hand eczema. Intervention 1: Intervention group: 10 patients are subjected to local spray of Wharton's jelly mesenchymal stem cell conditioned medium and erbium laser 3 times with an interval of 1 month. Intervention 2: Control group: 10 patients are subjected to topical triamcinolone spray and erbium laser 3 times with an interval of 1 month. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is -
public Sona Zare
No 4, Maryam Alley, South Kamraniyeh Street
Tehran Iran (Islamic Republic of) 1937957511 +98 21 2665 7438 sonazarebio@gmail.com Skin and Stem cell Research Center of Tehran University of Medical Sciences scientific Mohammad Ali Nilforoushzadeh
No 4, Maryam Alley, South Kamraniyeh Street
Tehran Iran (Islamic Republic of) 1937957511 +98 21 2665 7438 nilforoosh@sina.tums.ac.ir Skin and Stem cell Research Center of Tehran University of Medical Sciences Iran (Islamic Republic of) Healthy patients with hand eczema who have not used any topical medication in the past 2 weeks or any systemic medication in the past month. 18 years 60 years Both Pregnancy Breastfeeding Severe sensitivity to the study drug L20.8 Diseases of the skin and subcutaneous tissue Treatment - Other Treatment - Other Intervention group: 10 patients are subjected to local spray of Wharton's jelly mesenchymal stem cell conditioned medium and erbium laser 3 times with an interval of 1 month. Control group: 10 patients are subjected to topical triamcinolone spray and erbium laser 3 times with an interval of 1 month. Reduce or improve hand eczema. Timepoint: before and two weeks after the end of the study. Method of measurement: Using Eczema Extent and Severity Scale (EASI). Tehran University of Medical Sciences Approved 2023-04-10 Research Ethics Committee of Tehran University of Medical Sciences Tehran University of Medical Sciences, Keshavarz blvd Tehran Tehran Iran (Islamic Republic of)