IRCT20200127046282N32 IRCT 2024-05-13 Tehran University of Medical Sciences Investigating the effectiveness of conditioned medium with IPL laser compared to extracellular vesicles with IPL laser in the treatment of rosacea Investigating the effectiveness of conditioning medium derived from Wharton's jelly tissue along with IPL laser Compared with Wharton jelly tissue-derived extracellular vesicles conditioned with IPL laser In the treatment of rosacea 2023-05-20 anticipated 30 Complete https://irct.ir/trial/67650 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization method: simple randomization, randomization unit: individual, randomization tool: random number table, total sample size of 30 patients with a history of rosacea in three groups, clinical trial phase: 1-2, Blinding description: Since the appearance of both products are completely similar in terms of color, smell and appearance, patients and doctors do not know about the intervention and control groups, and the study will be considered double-blind. 1-2 Rosacea. Intervention 1: Intervention group: After performing the IPL laser, the patients are subjected to the local spray of 5 cc human Wharton's jelly mesenchymal stem cell conditioned medium (Produced by Zist Sakht Bianyan Pars Company - Iran), 3 times with an interval of 1 month. Intervention 2: Intervention group: After performing IPL laser, patients are subjected to local spray of 5 cc extracellular vesicles conditioned medium of human mesenchymal stem cells of Wharton's jelly (Produced by Zist Sakht Bianyan Pars Company - Iran), 3 times with an interval of 1 month. Intervention 3: Control group: Patients treated with IPL laser are subjected to a local spray of 5 cc of normal saline, 3 times with an interval of 1 month. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is -