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IRCT20220510054805N2 IRCT 2022-12-30 Islamic Azad University The comparison of the effect of metronidazole gel as an adjuant to mechanical debridementand mechanical debridement alone in peri-implantitis treatment The comparison of the effect of metronidazole gel as an adjuant to mechanical debridementand mechanical debridement alone in peri-implantitis treatment 2022-12-31 anticipated 32 Complete https://irct.ir/trial/67639 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The selection of participants in the study will be done by a simple random method, individually and with a random number table tool. In this way, a number is written in front of the name of each person from the client list, and then a table will be prepared based on the sample size. The selected numbers will be included in the study if they are eligible after the examination. The study will be conducted with a parallel design in which the selection of the desired patient for intervention or control is done randomly with a coin tool. For the patient if it is head, mechanical debridement will be performed along with metronidazole gel, and if is tails, mechanical debridement will be performed alone, Blinding description: Participant: will not know whether they are receiving drug or placebo. Researcher and therapist: In terms of packaging, color and consistency, medicinal gel and placebo are completely similar and are named only with letters A and B. Data analyzer: The data is evaluated numerically without specifying the side with gel and placebo. 3 peri-implantitis. Intervention 1: Intervention group: after the initial sampling, mechanical debridement and health education, metronidazole gel in the intended injection sites and the clinical parameters of the gums are measured again after 1 and 3 months. Intervention 2: Control group: After the initial sampling, mechanical debridement and health education, placebo in the injection sites and the clinical parameters of the gums are measured again after 1 and 3 months. Yes - There is a plan to make this available What will be shared: all When: 1402 To whom: all Conditions: Research Where to obtain: dr khorramdel How to obtain: The usual process Comments:
public Azin Khorramdel
Complex No. 2 of Islamic Azad University, Tabriz branch
Tabriz Iran (Islamic Republic of) 5157944533 +98 41 3637 7707 A_khorramdel@yahoo.com Islamic Azad University scientific Azin Khorramdel
Third floor, Rush building, Waliasr
Tabriz Iran (Islamic Republic of) 5155673547 +98 41 3329 6007 A_khorramdel@yahoo.com Islamic Azad University Iran (Islamic Republic of) Age greater than or equal to 20 years بیمار مبتلا به پری ایمپلنتایتیس 20 years no limit Both pregnancy breastfeeding Taking anticoagulants underlying disease (diabetes, kidney disorders, etc.) smoking M27.69 Other endosseous dental implant failure Treatment - Drugs Placebo Intervention group: after the initial sampling, mechanical debridement and health education, metronidazole gel in the intended injection sites and the clinical parameters of the gums are measured again after 1 and 3 months. Control group: After the initial sampling, mechanical debridement and health education, placebo in the injection sites and the clinical parameters of the gums are measured again after 1 and 3 months. Bleeding during probing. Timepoint: Before starting the intervention and 1 and 3 months after the treatment. Method of measurement: up to 30 seconds after probing, the probed areas are evaluated and in case of visible bleeding, it is recorded in the patient's chart and reported as a percentage for each implant. Islamic Azad University Approved 2022-12-13 research ethics commitees of islamic azad university-tabriz branch Complex No. 2 of Islamic Azad University, Tabriz branch, To Basmenj, Ahr Tee, Tabriz tabriz East Azarbaijan Iran (Islamic Republic of)