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IRCT20221211056777N1 IRCT 2023-01-22 Shahre-kord University of Medical Sciences Evaluation the effect of co-enzyme Q10 in patients with thalassemia major Evaluation the effect of co-enzyme Q10 supplementation on inhibition of ferroptosis in patients with thalassemia major referred to Shahrekord Hajer Hospital 2023-03-02 anticipated 50 Complete https://irct.ir/trial/67592 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Not used, Assignment: Single, Purpose: Supportive, Other design features: *, Blinding description: The data analyst does not know whether the collected data are related to before or after the intervention. 1 thalassemia major. 50 patients with thalassemia major are selected. The laboratory parameters (superoxide dismutase (SOD), catalase and glutathione peroxidase, ferritin, hemoglobin, ESR and CRP) will be checked by ELISA method for these patients before start intervention (baseline), and then, after eight weeks of taking one 100 mg Q10 tablet (Golden Life Company) daily.. Yes - There is a plan to make this available What will be shared: To share the data and documents of this research, only the information related to the main outcome will be shared. Also, files that can be published and do not violate people's privacy will be published. When: The access period will start 6 months after the results are published. To whom: Our data will only be available to researchers working in academic and scientific institutions Conditions: If there are conditions, all our data will be shared except personal information of people. The use of our data will only be allowed for similar research and review of our data by other researchers. All those who work in universities and scientific centers and decide to conduct similar research or check the accuracy of our data can access our data. Where to obtain: In order to receive information, all eligible people can collect data by referring to the person in charge of the project. The contact methods are the email address shimarahmati1987@gmail.com or the contact number 00989139854865 How to obtain: To receive information after sending the request, the requests will be reviewed within 10 days. If the above conditions are met, the information will be sent to the provided email within 30 days at most. Comments:
public Shima Rahmati
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Shahrekord Iran (Islamic Republic of) 8816754633 +98 38 3222 0016 shimarahmati1987@gmail.com Shahre-kord University of Medical Sciences scientific Kiavash Fekri
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Shahrekor Iran (Islamic Republic of) 8816754633 0383222116 k.fekri@muk.ac.ir Shahre-kord University of Medical Sciences Iran (Islamic Republic of) patient with thalassemia major no limit no limit Both Non-cooperation of the patient The presence of side effects People who suffer from infection and inflammation. Death of the patient D56.1 Beta thalassemia Treatment - Drugs 50 patients with thalassemia major are selected. The laboratory parameters (superoxide dismutase (SOD), catalase and glutathione peroxidase, ferritin, hemoglobin, ESR and CRP) will be checked by ELISA method for these patients before start intervention (baseline), and then, after eight weeks of taking one 100 mg Q10 tablet (Golden Life Company) daily. The level of superoxide dismutase, catalase and peroxidase enzymes and ferritin serum level. ESR, CRP. Timepoint: Before the intervention and eight weeks after the intervention. Method of measurement: ELISA test kit. Shahre-kord University of Medical Sciences Approved 2022-10-04 Ethics Committee of Shahrekord University of Medical Sciences Kashani street Shahrekord Chahar-Mahal-va-Bakhtiari Iran (Islamic Republic of)