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IRCT20221215056829N1 IRCT 2022-12-20 Pak Emirates Military Hospital narrow band UVB for post herpetic neuralgia (PHN) Effect of narrow band UVB in combination with oral Acyclovir versus oral Acyclovir alone in prevention of Post Herpetic Neuralgia in patients with Herpes Zoster 2020-11-11 anticipated 100 Complete https://irct.ir/trial/67484 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Randomization was conducted through sequentially numbered opaque envelopes generated from a random numbers table into two groups of 50 patients each. Each patient was assigned a number at enrollment which defined a study assignment (Oral Acyclovir alone vs Oral Acyclovir plus nbUVB). N/A Patients suffering from Herpes Zoster and presenting within 7 days of onset of rash. Intervention 1: Intervention group: 50 patients received oral Acyclovir 800mg five times daily for 07 days along with analgesic Paracetamol ± Gabapentin, plus nbUVB delivered only to the affected dermatome while the rest of body was covered with clothing. The starting dose of nbUVB was 0.21 J/cm2 and it was increased by increment of 10% on every session as long as no adverse effects including persistent erythema, burning or itching were reported by the patient. The sessions were repeated 03 times per week to a maximum of 15 sessions or less if the pain settles completely. Intervention 2: Control group: 50 patients received oral Acyclovir 800mg five times daily for 07 days along with analgesic Paracetamol ± Gabapentin. nbUVB was not administered to this group. Yes - There is a plan to make this available What will be shared: Effect of narrow band UVB in prevention of post herpetic neuralgia When: starting 1 month after publication To whom: people working in academic institutions Conditions: data will be allowed to use after taking permission from the author Where to obtain: data will be obtainable from author Abrar Ahmad Khalid, abrar2437@gmail.com How to obtain: A request to be sent via given email address Comments:
public Abrar Ahmad Khalid
Abid Majeed Road
Rawalpindi Pakistan 46000 +92 333 8511241 abrar2437@gmail.com Pak Emirates Military Hospital scientific Abrar Ahmad Khalid
Abid Majeed Road
Rawalpindi Pakistan 46000 +92 333 8511241 abrar2437@gmail.com Pak Emirates Military Hospital Pakistan Both genders Patients having herpes zoster as per operational definition, reporting within 07 days of eruption of vesicles no limit no limit Both Patients reporting after 07 days of onset of rash Patients having history of photosensitivity Patients who are unable to stand due to any musculoskeletal abnormalities Patients who are claustrophobic Patients in which genitalia is involved (L1 dermatome), as genitalia is usually shielded during nbUVB irradiation Patients in which scalp is involved (C2 dermatome), as because of hair scalp will not be properly irradiated B02 Zoster [herpes zoster] Treatment - Devices Treatment - Drugs Intervention group: 50 patients received oral Acyclovir 800mg five times daily for 07 days along with analgesic Paracetamol ± Gabapentin, plus nbUVB delivered only to the affected dermatome while the rest of body was covered with clothing. The starting dose of nbUVB was 0.21 J/cm2 and it was increased by increment of 10% on every session as long as no adverse effects including persistent erythema, burning or itching were reported by the patient. The sessions were repeated 03 times per week to a maximum of 15 sessions or less if the pain settles completely. Control group: 50 patients received oral Acyclovir 800mg five times daily for 07 days along with analgesic Paracetamol ± Gabapentin. nbUVB was not administered to this group. Post herpetic neuralgia. Timepoint: At completion of treatment and after 3 months. Method of measurement: Verbal Rating Score. Pak Emirates Military Hospital Approved 2020-09-02 Ethical Review Committee and Research Department Pak Emirates Military Hospital Abid Majeed Road Rawalpindi Punjab Pakistan