IRCT20221216056832N1 IRCT 2023-02-01 Babol University of Medical Sciences Investigating the effect of celecoxib on the treatment of bipolar disorder Investigating the effectiveness of adding celecoxib to sodium valproate in the treatment of patients with bipolar disorder 2022-12-31 anticipated 60 Complete https://irct.ir/trial/67459 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be done using permutation blocks. In this method, the size of the blocks will be 4 and the ratio of two groups in each block will be 1:1. In each block, there will be an equal number of each group, i.e. (2 valproate + placebo) and (2 valproate + celecoxib). In each block, the arrangement of two groups is in random order and this random order was determined by a statistician. In order to hide the treatment process, random codes are written on the medicine canisters, and when drugs are allocated, the codes are recorded on the patients' files. The opening of the codes will be done by a statistician after the study is completed, Blinding description: In order to hide the treatment process, random codes are written on the medicine cans, and when drugs are allocated, the codes are recorded on the patients' files. In case of side effects, the codes are opened. Otherwise, the codes will be opened and analyzed at the end of the study. The use of placebo medicine will be used in a completely similar way in terms of shape and color in the same package. A placebo (oral capsule containing 1000 mg of lactose) is made. 3 Bipolar Disorder. Intervention 1: Intervention group: including 30 people in the group treated with celecoxib 400mg along with sodium valproate 20mg/kg daily for 8 weeks. Intervention 2: Control group: 30 children will be treated with placebo (oral capsule containing 1000 mg lactose) and sodium valproate 20 mg/kg. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.