IRCT20221214056816N1 IRCT 2023-02-12 Zanjan University of Medical Sciences effectiveness of transcranial direct current stimulation and varenicline on, excutive function, cravings and,depression, anxiety and stress in smokers with major depressive disorder Comparison and Combination the effectiveness of transcranial direct current stimulation and varenicline on excutive function, cravings, depression, anxiety and stress in smokers with major depressive disorder 2023-02-05 anticipated 100 Complete https://irct.ir/trial/67421 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization is done through simple random method using coin toss. In this way, subjects are randomly assigned to treatment and control groups, Blinding description: Blinding will be done in such a way that the subjects and the therapist are not aware of the assignment to the groups and the statistical analyst will also be blind to the therapist and the subjects. 2 People with smoking. Intervention 1: Intervention group: common protocol to reduce cravings in smokers through extracranial stimulation device (tDCS), placing the stimulating electrode (anode) on the right dorsolateral prefrontal cortex (DLPFC) and the inhibitory electrode (cathode), prefrontal cortex The dorsal side is left. Intervention 2: Intervention group: The use of varenicline is usually started as follows: the first three days, one tablet of 500 micrograms daily, days 4 to 7 one tablet (500 micrograms), from the 8th day onwards, one tablet of 1 mg twice a day. The complete period of taking varenicline is 12 weeks. It is possible that according to the doctor's opinion, in case of success in quitting smoking, it may continue for more than 12 weeks. Intervention 3: Intervention group: The protocol for the sham group is through the extracranial stimulation device (tDCS), placing the stimulating electrode (anode) on the right dorsolateral prefrontal cortex (DLPFC) and the inhibitory electrode (cathode) on the left dorsolateral prefrontal cortex. It runs for 40 seconds. No - There is not a plan to make this available Justification or reason for not sharing IPD is Due to the confidentiality of each person's private data, the data is shared in the form of an article.