IRCT20221207056743N1 IRCT 2023-03-29 Ghoum University of Medical Sciences Comparison the effect of saffron extract with artificial saliva on alleviation of oral mucositis caused by head and neck radiotherapy: a randomized trial Comparison the effect of saffron extract with artificial saliva on alleviation of oral mucositis caused by head and neck radiotherapy: a randomized trial 2023-04-09 anticipated 62 Complete https://irct.ir/trial/67378 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are divided into two groups using the randomized balanced block method with block sizes of 4 and 6. The random sequence is generated by an epidemiologist by running an online program on the website (https://www.sealedenvelope.com). Allocation concealment is also guaranteed due to the use of special codes generated by the website, Blinding description: The treating physician and the statistical analyst are unaware of the allocation of the type of treatment to the patients, and the information is collected by a researcher outside the treatment and statistics team in the form of coding. 3 Oral mucositis. Intervention 1: Intervention group: the group receiving common treatments to prevent mucositis plus receiving a daily puff of saffron, which is equivalent to 100 milligrams of saffron with a concentration of 1%. After using the spray, patients do not wash their mouths for thirty minutes and do not eat They don't eat either. The duration of use is 4 weeks. Intervention 2: Control group: recipients of usual mucositis treatments plus a daily puff of mucosamine artificial saliva spray. The duration of use is 4 weeks. No - There is not a plan to make this available Justification or reason for not sharing IPD is No further information exists