IRCT20220818055740N3 IRCT 2023-02-28 Shahre-kord University of Medical Sciences Title : Clinical evaluation of the effect of the combination of herbal cream containing Rosmarinus officinalis, , Malva sylvestris, Foeniculum vulgare extract and Oenothera biennis and Bitter Almond Oil for treatment of hair loos on patients with Areata Alopecia Title : Clinical evaluation of the effect of the combination of herbal cream containing Rosmarinus officinalis, , Malva sylvestris, Foeniculum vulgare extract and Oenothera biennis and Bitter Almond Oil for treatment of hair loos on patients with Areata Alopecia 2018-10-07 anticipated 150 Complete https://irct.ir/trial/67348 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Samples were 150 patients and were selected by simple random sampling and Random assignment or random placement that is an experimental technique for assigning human participants or animal subjects to different groups in an experiment (e.g., a treatment group versus a control group) using randomization, such as by a chance procedure (e.g., flipping a coin). This ensures that each participant or subject has an equal chance of being placed in any group. Moreover, grouping of samples has been done using Randomizer(RA) software. Patients were divided into 6 groups of 25. For each treated group, a control group (triamcinolone cream) was placed separately, and the entrance of patients into these groups is random. Grouping of samples has been done using RA software. The blinding of this research is on behalf of the patient and the drug distributor. The homogenization of the studied groups is based on the variables: sex, age, type of alopecia areata and severity of hair loss in the head area. In general, randomization of patients was done based on coding, Blinding description: The single blindness of the study was performed in this process that at first the mentioned drugs received code without any labels and the patient selected one of the two drugs randomly. Then, the name of each person and the drug code provided to him registered by the secretary. Neither the patient nor the doctor was not aware of the type of medication. The name of each person and his drug was specified only during analyzing the data, and completed the patients' information profile by mentioning the name of the drug received by them. 2-3 Hair loss in patients with alopecia areata. Intervention 1: IMen treated with minoxidil and herbal cream prepared daily and checked up by a doctor monthly- Women with alopecia areata (AA) who are treated with minoxidil and herbal cream prepared daily and checked-up by a doctor monthly. Intervention 2: - Men with alopecia areata (AA) treated with minoxidil daily and triamcinolone cream and checked-up by a doctor monthly (control group).- Men with alopecia areata (AA) who are treated with minoxidil and placebo (cream without ingredients) daily and checked-up by a doctor monthly.- Women with alopecia areata (AA) treated with minoxidil daily and triamcinolone cream and checked-up by a doctor monthly (control group).- Women with alopecia areata (AA) who are treated with minoxidil and placebo (cream without ingredients) daily and checked-up by a physician monthly. No - There is not a plan to make this available Justification or reason for not sharing IPD is The project needs to complete.