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IRCT20180409039247N3 IRCT 2022-12-20 Tehran University of Medical Sciences - Research Assistant Comparison of the effect of TNG, misoprostol, dexamethasone and Foley tube along with acetaminophen on the process of dilatation and effusion in childbirth Comparative study of the effects of TNG, misoprostol, dexamethasone and Foley catheter with acetaminophen on the process effacement and dilatation in the inactive and active phase of labor 2023-01-21 anticipated 240 Complete https://irct.ir/trial/67284 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The method of randomizing the table of random numbers is vital statistics reference books. N/A Increasing the success rate in vaginal delivery. Intervention 1: Intervention group: The content of the 400 micro TNG tablet is diluted with 1 cc of serum and poured into the cervix (repeat after 4 and 6 hours if Bishop does not improve). Intervention 2: Intervention group: 8 mg of dexamethasone is injected intramuscularly (this arm is one time and does not repeat). Intervention 3: Intervention group:The Foley catheter is inserted into the cervix with 500 ml of water (maximum 12 hours). Foley is 16 and the bottle is filled with 30 cc. If it does not turn off, it will automatically turn off after 12 hours. Intervention 4: Control group: 25 microns of misoprostol is placed under the tongue (if Bishop does not improve over 4, it is repeated after 6 hours). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Fahimeh Ghotbizadeh
Imam hospital, East Bagherkhan St.
Tehran Iran (Islamic Republic of) 141973314 +98 21 6119 0000 fghotbizadeh@yahoo.com Tehran University of Medical Sciences scientific Fahimeh Ghotbizadeh
Imam hospital, East Bagherkhan St.
Tehran Iran (Islamic Republic of) 1419733141 +98 21 6119 0000 fghotbizadeh@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) Age 18-40 years old Gestational age > 37 weeks Singleton pregnancy Cephalic presentation Gravid 1 18 years 40 years Female Cephalopelvic incompatibility Maternal medical diseases Fetal distress Uterine scar Sensitivity to studied drugs Treatment - Drugs Treatment - Drugs Treatment - Devices Treatment - Drugs Intervention group: The content of the 400 micro TNG tablet is diluted with 1 cc of serum and poured into the cervix (repeat after 4 and 6 hours if Bishop does not improve) Intervention group: 8 mg of dexamethasone is injected intramuscularly (this arm is one time and does not repeat) Intervention group:The Foley catheter is inserted into the cervix with 500 ml of water (maximum 12 hours). Foley is 16 and the bottle is filled with 30 cc. If it does not turn off, it will automatically turn off after 12 hours. Control group: 25 microns of misoprostol is placed under the tongue (if Bishop does not improve over 4, it is repeated after 6 hours) The time interval of hospitalization for the termination of pregnancy until delivery. Timepoint: Every 6 hours. Method of measurement: Minutes. Reducing the cesarean rate. Timepoint: At the end of the labor phase. Method of measurement: Has she had a caesarean section?. Tehran University of Medical Sciences - Research Assistant Approved 2022-11-15 Ethics committee in the research of Imam Khomeini hospital complex Imam complex, East Bagherkhan street, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)