IRCT201608086280N10 IRCT 2016-10-02 Vice chancellor for research, Guilan University of Medical Sciences The Effect of remifentanil on Mini-mental status examination after electroconvulsive therapy in major depressive patients. Evaluation of the incidence and severity of cognitive impairment after electroconvulsive therapy under general anesthesia with remifentanil in patients referred to electroconvulsive therapy shaft center , Rasht in 1395 2016-09-05 anticipated 60 Complete https://irct.ir/trial/6727 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 The Patients With Major Depressive Disease. Intervention 1: In intervention group , the patients will receive remifentanil as the sole agent anesthetic with doses : 4-8 µg/kg ,and the suuccynilcholine will administerd for relaxation.The patients will ventilate by bag and mask with 100% of oxygen till the bi-temporal electrode will insert. The patients will observe in recovery until to fully awake position. Time of seizure and time of awakening also will record. All the patients are visited by psychiatrist to evaluated the minimental status examination before and 5 and 24 hours after electro convulsive therapy. Intervention 2: In control group the patients will receive thiopental 4 mg/kg with equal volume of that prepare by normal saline. The patients will ventilated by bag and mask with 100% of oxygen till the bi-temporal electrode will insert. The patients will observe in recovery until to fully awake position. Time of seizure and time of awakening also will record. All the patients are visited by psychiatrist to evaluated the (Mini Mental Status Exam ) MMSE before and 5 and 24 hours after electro convulsive therapy.