IRCT20220930056059N2 IRCT 2022-12-28 Tabriz University of Medical Sciences Comparison of the effect of Evening primrose oil with Misoprostol on cervical ripening before hysteroscopy in women without a previous vaginal delivery. Comparison of the effect of Evening primrose oil with Misoprostol on cervical ripening before hysteroscopy in women without a previous vaginal delivery. A double-blind clinical trial 2022-12-31 anticipated 100 Complete https://irct.ir/trial/67254 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The treatment allocation list is already designed on Block Balanced Randomization Method by the computer software. 1 (A), 2 (B), 3 (B), 4 (B), 5 (A),……. Any eligible patient will be given a 1 to 100 code after obtaining informed consent in order to visit the clinic and based on the above block, they receive A or B drug. The drug distributor doesn’t have a role in the treatment plan and data analysis.Data analyzer are not aware of the type of treatment for each patient. Finally, the patients will be followed by their own codes, Blinding description: Outcome assessors and data analysts will not have information on how to assign groups to patients in groups A and B. We divide the outcome assessor and the patient data analyzer into A and B know and do not know the nature of groups. 3 Leiomyoma of uterus. Intervention 1: Intervention group: 1 capsules of evening primrose 1000 mg (made by Dana Pharma company)is inserted in the posterior fornix 4 to 6 hours before surgery. Intervention 2: Control group:200 micrograms of misoprostol ( Behestan Daru Company) is inserted in the posterior fornix 4 to 6 hours before surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After the completion of the project, the decision will be made.