IRCT201509056280N8 IRCT 2015-10-24 Vice Chancellaor foe Research of Guilan University of Medical Sciences the use of topical tranexamic acid in total hip arthroplasty The comparison of intravenous tranexamic acid and topical tranexamic acid efficacy on postoperative bleeding after total hip arthroplasty surgery. 2015-10-23 anticipated 100 Complete https://irct.ir/trial/6725 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 2 Patients candidate for total hip arthroplasty. Intervention 1: . In intravenous tranexamic acid group (15mg/kg), transamine will administer by anesthesiologist and based on body weight in a time of 10 minute. Before skin incision and surgery, all the patients receive only the intravenous form of tranexamic acid .Tranexamic acid is produced in CASPIAN TAMIN pharmaceutical co. Each vial consists of 500mg of tranexamic acid in 5 ml. Intervention 2: In tranexamic topical group,patients will recieve 3gr of tranexamic acid(6 vials) that diluted with normal saline intraoperatively by orthoped.After rimming of acetabulom 30 ml of above solution inserted in acetabulom and wound and keeping there about 1 minute. After broaching the femoral canal 30 ml of topical tranexamic acid inserted and keeping there about 1 min. the remain solution (30 ml )insert in the wound after hip joint reduction and will repaired.