IRCT201503266280N6 IRCT 2015-04-29 Vice Chancellor For Research OF Guilan University of Medical Sciences The Compsrison Between Two Drug Ketamine and Propofol On Cognition After ECT A DOUBLE BLIND CLINICAL RANDOMIZED TRIAL OF ASSESSMENT OF KETAMINE ADDED TO PROPOFOL ON MMSE SCORE AFTER ECT IN MAJOR DEPRESSION PATIENTS 2015-05-06 anticipated 120 Complete https://irct.ir/trial/6724 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Other design features: we used electronical softwre to generate the random allocation sequence. N/A MAJOR DEPRESSION. Intervention 1: In intervention group , patients will receive ketofol (ketamine 0.5 mg/kg , propofol 0.5 mg/kg mixture )and the suuccynilcholine for relaxation. The patients will ventilate by bag and mask with 100% of oxygen till the bitemporal electrode will insert. Intervention 2: In control group the patients will receive propofol 1mg/kg with equal volume of ketamine that prepare by normal saline. The patients will ventilate by bag and mask with 100% of oxygen till the bitemporal electrode will insert. The patients will observe in recovery until to fully awake position. Time of seizure and time of awakening also will record.