IRCT20120910010800N9 IRCT 2022-12-07 Shahid Beheshti University of Medical Sciences Effect of celecoxib on pain control after orthopedic surgery Effects of Preoperative Celecoxib Administration on Pain Control After Tibial Fracture Surgery 2022-12-21 anticipated 450 Complete https://irct.ir/trial/67160 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: At the time of admission in the operating room recovery, patients will be selected by permutation block method using random numbers obtained from the table of random numbers written on the card, which will be placed in sealed non-transparent envelopes by an anesthesia technician who is in The next stages of the non-interventional design will be equally divided into one of the following groups: celecoxib 100 mg group (A), celecoxib 200 mg group (B), celecoxib 400 mg group (C), and placebo group. (O), Blinding description: In this study, 100 mg celecoxib capsules and placebo capsules will be used, in which the celecoxib content of the capsule is replaced with an approved artificial sweetener powder. These capsules will be placed inside the envelopes during the preparation of the envelopes of the groups. One hour before the operation and during recovery, group A patients will receive one celecoxib capsule and three placebo capsules, group B patients will receive two celecoxib capsules and two placebo capsules, group C patients will receive four celecoxib capsules, and group O patients will receive four placebo capsules. The next follow-up of the patients and data recording will be done by the anesthesiologist who is not aware of the patient group. 3 Comminuted fracture of shaft of tibia. Intervention 1: Intervention group: Group A patients receive one celecoxib capsule and three placebo capsules one hour before surgery. Intervention 2: Intervention group: Intervention group: Group B patients receive two celecoxib capsules and two placebo capsules. Intervention 3: Intervention group: Group C patients receive four celecoxib capsules. Intervention 4: Control group: Control group: Group O patients receive four placebo capsules. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after unidentified individuals. When: One year after the publication of the article. To whom: All jobs Conditions: All non-personal patient information (anonymously) can be accessed by contacting the responsible author. Where to obtain: Email to: drdariushabtahi@yahoo.com How to obtain: Sending email and review by the responsible author Comments: