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IRCT20221127056631N1 IRCT 2022-12-03 Zahedan University of Medical Sciences Evaluation of neuroprotective effect of Brimonidine on visual indices in optic neuritis patients ENEB Comparing the neuroprotective effect of Brimonidine and placebo on visual indices in optic neuritis patients 2022-12-01 anticipated 60 Complete https://irct.ir/trial/67046 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The random allocation of patients to two groups is done by the permutation block stratified randomization method. First, eligible referring patients are classified according to age and gender in the order of arrival. Then they are assigned to the desired group based on blocks of 4 (consisting of two groups A and B and two repetitions for each) randomly selected from among all the possible states of permutations, Blinding description: Single blinding method is used in this research. So that the patient will not be aware of the intervention. 3 Optic neuritis. Intervention 1: Intervention group: Routine interventions and brimonidine drops 0.2%. Intervention 2: Control group: Routine interventions and artificial tear placebo drops. Yes - There is a plan to make this available What will be shared: All data When: All time To whom: All person Conditions: To improve the treatment and research process Where to obtain: Contact my personal email at Dr.mahdiasani@yahoo.com or phone number 00989117721785 in the name of Dr. Asani so that the information can be sent to them as a file. How to obtain: Information will be sent about ten days after the email Comments:
public Mahdi Asani
Motahari Blvd., Zahedan
Zahedan Iran (Islamic Republic of) 9813637461 +98 17 3243 4564 Dr.Mahdiasani@zaums.ac.ir Zahedan University of Medical Sciences scientific Mohammad Arish
Motahari Blvd., Zahedan
Zahedan Iran (Islamic Republic of) 9813637461 +98 17 3346 5676 Dr.mohahadarish@zaums.ac.ir Zahedan University of Medical Sciences Iran (Islamic Republic of) Informed and free consent to participate in the study Acute optic neuritis The age range of patients is 18 to 45 years Spherical equivalent refractive error of three diopters of myopia to one and a half diopters of hyperopia 18 years 45 years Both History of optic neuritis in another normal eye Use or history of using drugs affecting the immune system History of any type of retinal surgery History of optic disc swelling in each eye Having amblyopia in one or both eyes Glaucoma Diabetic retinopathy or any type of maculopathy Color blindness H46 Optic neuritis Treatment - Drugs Placebo Intervention group: Routine interventions and brimonidine drops 0.2% Control group: Routine interventions and artificial tear placebo drops Visual acuity. Timepoint: Measurement on the first day and one month later and three months later. Method of measurement: Visual acuity measured by Snellen's chart. Contrast sensivity. Timepoint: Measurement on the first day and one month later and three months later. Method of measurement: Contrast sensitivity measured by Young's chart. Color vision. Timepoint: Measurement on the first day and one month later and three months later. Method of measurement: Color vision as measured by the Ishihara chart. Zahedan University of Medical Sciences Approved 2022-04-10 Ethics committee of zahedan University of Medical Sciences Medical Sciences Campus., Dr. Hasabi Square., Zahedan Zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)