IRCT20160920029889N4 IRCT 2023-01-07 Mazandaran University of Medical Sciences Effect of Colchicine on aphthous ulceration. Investigation the clinical efficacy of Colchicine-loaded polymeric nanofibers on aphthous ulceration, A Pilot Study 2023-01-14 anticipated 10 Complete https://irct.ir/trial/66858 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: First, eligible patients will be selected non-randomized, sequential. Then these patients are coded using computer random allocation software, and then the codes are divided into two parts, and each part of the codes will be assigned to a group. 2 Aphthous. Intervention 1: Intervention group: A circular piece of polymer nanofibers with a diameter of 1.2 cm containing 1 mg of colchicine is prescribed to each patient and he will be taught to place the piece directly on the aphthous lesion without drying the mucous membrane of the wound. then it will be emphasized that the mouth should be open for two minutes and after connecting the nanofiber mat to the relevant surface, refrain from moving it with the help of the tongue so that the medicine is released slowly. This procedure is performed 3 times a day. The patient will be taught that if the mucous surface is dry before using the medicine, after placing the mat on the lesion, ensure that the mat is moistened. In addition, the medicine should be used after eating and avoid eating and drinking for an hour after that. Intervention 2: Control group: each patient will be given a package and will be taught to first dry the mucous surface of the wound slowly and then soak a small piece of sanitary cotton measuring about 3 x 3 centimeters with medicine and place it on the infected lesion. Then it will be emphasized that the mouth should be open for two minutes and perform this action 3 times a day. The patient will be taught to use the medicine after eating and to avoid eating and drinking for an hour after. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information