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IRCT20200127046282N24 IRCT 2023-02-18 Tehran University of Medical Sciences Comparison of the safety and efficacy of the combination of Wharton's jelly mesenchymal stem cells conditioned medium and platelet-rich plasma and liposomal of Wharton's jelly mesenchymal stem cells conditioned medium and platelet-rich plasma in the treatment of androgenetic alopecia Comparison of safety and efficacy of Wharton's jelly mesenchymal stem cells conditioned medium and Platelet-Rich Plasma (WJMSCs CM-PRP) and liposomal Wharton's jelly mesenchymal stem cells conditioned medium-Platelet-Rich Plasma (Liposomal WJMSCs CM-PRP) in androgenetic alopecia 2023-02-20 anticipated 20 Complete https://irct.ir/trial/66791 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block Balanced Randomization, Blinding description: Two dermatologists who are responsible for comparing the photos of patients before and after treatment. 1-2 Androgenetic alopecia. Intervention 1: Intervention group: patients will use liposomal conditioned medium-platelet rich plasma daily for three months. Intervention 2: Control group: patients will receive conditioned medium-platelet-rich plasma product three times with an interval of one month as an injection. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is -
public Sona Zare
No. 4, Maryam Alley, South Kamraniye St.
Tehran Iran (Islamic Republic of) 1937957511 +98 21 2665 7438 sonazarebio@gmail.com Tehran University of Medical Sciences scientific Mohammad Ali Nilforoushzadeh
No. 4, Maryam Alley, South Kamraniye St.
Tehran Iran (Islamic Republic of) 1937957511 +98 21 2665 7438 Dr_nilforoush@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) Not using topical or oral medication for the treatment of alopecia during the last six months AGA type 2-4 18 years 50 years Both Age under18 years pregnancy breastfeeding History of malignant diseases Taking any topical or systemic treatment during the study L64.9 Androgenic alopecia, unspecified Treatment - Other Treatment - Other Intervention group: patients will use liposomal conditioned medium-platelet rich plasma daily for three months. Control group: patients will receive conditioned medium-platelet-rich plasma product three times with an interval of one month as an injection. Hair density. Timepoint: Before starting the treatment, the end of the first, second, third month and one month after the end of the treatment period (end of the fourth month). Method of measurement: Biometric examination will be done and the findings from VISIOFACE and TES-TB (hair loss type with X1 lens, hair density and scalp condition with X60Triple lens, hair diameter and PORE condition with KPL X150 lens and hair shaft surface condition with X700 lens) It will be recorded for each patient. Side effects. Timepoint: One week after session. Method of measurement: Questionnaire and visit. Satisfaction. Timepoint: One months after the last session. Method of measurement: Satisfaction Questionnaire and visit. Tolerability. Timepoint: Each session after transplantation. Method of measurement: Questionnaire and visit. Tehran University of Medical Sciences Approved 2022-10-03 Research Ethics Committee of Tehran University of Medical Sciences Tehran University of Medical Sciences, Keshavarz Boulevard, Tehran Tehran Iran (Islamic Republic of)