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IRCT20221015056178N1 IRCT 2023-08-08 Islamic Azad University Evaluation of the preoperative effect of Mirtazapine administration on reducing postoperative pain, in hospitals affiliated with Islamic Azad University of Tehran in 2023 76 patients who are candidates for surgery in hospitals affiliated with Islamic Azad University of Tehran are randomly divided into two groups. One hour before surgery, Mirtazapine will be given to the intervention group and placebo to the control group. After transferring the patients to the ward, the pain level of the patients is measured serially. We want to evaluate the preoperative effect of Mirtazapine administration on reducing postoperative pain (pain severity and duration of pain relief). 2023-08-12 anticipated 76 Complete https://irct.ir/trial/66346 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Used, Assignment: Single, Purpose: Prevention, Blinding description: The intervention group receives mirtazapine with the aim of reducing pain after surgery, while the control group with the same goal is prescribed placebo under the name of B-complex. In this one-sided blind study, the researcher is aware of the recipients of mirtazapine and placebo, but the participants have been blinded to the study groups after obtaining informed consent. The members of the intervention and control groups were randomly selected and there are no special conditions for the classification of patients in this study. The purpose of blinding this clinical trial to the patients receiving the drugs is to investigate the analgesic effects of mirtazapine as best and accurately as possible and to avoid the involvement of confounding factors that affect the results of this study. 3 postoperative pain. Intervention 1: Intervention group: Mirtazapine. Intervention 2: Control group: B-Complex. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.
public Mobina Niazi Nasihati
No. 4, Ghazizadeh Alley, Araqi St. , 2nd Bustan St. , Pasdaran Ave.
Tehran Iran (Islamic Republic of) 1664913670 +98 21 2230 8901 Niazi.mobina@yahoo.com Islamic Azad University scientific Mobina Niazi Nasihati
No. 4, Ghazizadeh Alley, Araqi St. , 2nd Bustan St. , Pasdaran Ave.
Tehran Iran (Islamic Republic of) 1664913670 +98 21 2230 8901 Niazi.mobina@yahoo.com Islamic Azad University Iran (Islamic Republic of) Patients who are candidates for surgery Insensitivity to Mirtazapine Age between 25 and 50 years BMI between 20 and 25 ASA one or two Patient consent to conduct a clinical trial 25 years 50 years Both Surgeries greater than an hour Emergency surgeries Pregnant women or the possibility of pregnancy Diabetic, cardiac, pulmonary and neurological patients Drug addiction Prevention Placebo Intervention group: Mirtazapine Control group: B-Complex Severity of postoperative pain. Timepoint: 2, 6 and 12 hours after leaving the operating room. Method of measurement: Visual Analogue Scale (facial experience). Islamic Azad University Approved 2022-06-13 Ethics Committee of Tehran Islamic Azad University of Medical Sciences Tehran Islamic Azad University of Medical Sciences, Khaqani St., Shariati St. Tehran Tehran Iran (Islamic Republic of)