IRCT20220614055167N2 IRCT 2023-01-25 Tabriz University of Medical Sciences Efficacy and safety of Turmeric, Black Seeds, Flaxseed and Medicago Sativa in patients with osteoarthritis The Joint Effects of Turmeric, Black Seeds, Flaxseed and Medicago Sativa for relieving symptoms of knee osteoarthritis: A Phase 1-2 Randomized, Double-Blind, Placebo-Controlled Clinical Trial 2023-09-01 anticipated 60 Complete https://irct.ir/trial/66296 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Using balanced block randomization, patients will be enrolled in one of the two groups, intervention (mixed cream of turmeric, flax seeds, Medicago Sativa, and black seeds) or placebo. The randomization sequence will be performed by an individual who will not participate in the current study. Moreover, the aforementioned randomization method reduces the chances of predicting and manipulating the randomization process and will lead to balanced sample sizes in both groups, both during the study and at the end of the study. The patients will all receive sealed boxes that are numbered with 10-digit codes and contain either the intervention or placebo creams, Blinding description: The patients will receive the boxes sealed with 10-digit codes and in the container of the original drug or placebo, and they will not be aware of the type of drug received, and the researcher will ensure the blinding of the patients. Also, doctors, researchers, and those responsible for the implementation of the project will not be aware of the type of medicine received by the patients until the end of the study. 1-2 Knee osteoarthritis. Intervention 1: Intervention group: Cream containing Turmeric, Black Seeds, Flaxseed, and Medicago Sativa. Intervention 2: Control group: Vaseline cream. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no additional information.