]>
IRCT20221004056088N1 IRCT 2022-10-15 Shahre-kord University of Medical Sciences Comparison the effect of Indomethacin and Diclofenac Sodium in reducing pain after surgical removal of mandibular third molar Comparison the prophylactic effect of Indomethacin and Diclofenac Sodium in reducing pain after surgical removal of mandibular horizontal impacted third molar 2022-10-08 anticipated 90 Complete https://irct.ir/trial/66272 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: They will be randomly divided into one of two groups, A and B, using the permutation block method, in one group of the painkiller indomethacin (Aria Pharmaceutical Company, Tehran, Iran) (75 mg) ) and in the other group, the painkiller diclofenac sodium tablet (Alborz Pharmaceutical Company, Qazvin, Iran) (100 mg) will be used as a pain prevention drug. Then, each person will be given one of the two types of drugs of group A or B, 30 minutes before the dental surgery. The study will be conducted in a triple-blind manner, Blinding description: The study will be conducted in a triple-blind manner so that blinding will be established for the maxillofacial specialist doctor, statistical analyst and volunteer patients. The blinding of the specialist doctor is done in such a way that the drugs will be given to the specialist doctor by his assistant, without his knowledge of the type of drug, in the same boxes named with A and B. On the other hand, to blind the patient, he will be told that he will be given one of the two drugs, indomethacin or diclofenac sodium, randomly and without his knowledge of its type. In order to blind the statistical analyst, the information will be provided to him in the form of two groups B and A, where the type of drug in each group is not known, and the result will be checked. 2-3 pain after surgical removal of mandibular horizontal impacted third molar. Intervention 1: Intervention group: Intervention group A will use indomethacin tablet painkiller as a pain prevention drug. Intervention 2: Intervention group: Intervention group B will use the painkiller diclofenac sodium tablet as a pain prevention drug. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Still undecided - no release schedule yet
public Babak Hasanalizadmazhar
Elahie
Tehran Iran (Islamic Republic of) 2222222222 . goooolnaz75@gmail.com Shahre-kord University of Medical Sciences scientific Alireza Tamizifar
Kashani Avenue
Shahrekord Iran (Islamic Republic of) 8817858912 +98 38 3222 1456 galexy9494@gmail.com Shahre-kord University of Medical Sciences Iran (Islamic Republic of) Patients' satisfaction with participating in the study Patients' satisfaction with participating in the study mandibular horizontal impacted third molar Patients without gastrointestinal ulcer Not taking painkillers or other drugs for 24 hours before surgery Not having a history of addiction to drugs or painkillers Patients who are not pregnant or breastfeeding. Known insensitivity to common non-steroidal anti-inflammatories and analgesics No history of nasal polyps, bronchospasm or angioedema caused by non-steroidal anti-inflammatory drugs. People who are able to take medicine orally. 18 years 35 years Both Dissatisfaction of patients to continue the study Those who have used ketorolac Prevention Prevention Intervention group: Intervention group A will use indomethacin tablet painkiller as a pain prevention drug. Intervention group: Intervention group B will use the painkiller diclofenac sodium tablet as a pain prevention drug. Pain. Timepoint: Pain 6 hours after surgery and pain 12 hours after surgery and pain 24 hours after surgery. Method of measurement: The level of pain expressed by patients after horizontal third molar surgery. Shahre-kord University of Medical Sciences Approved 2022-10-04 Ethics committee of Shahrekord University of Medical Sciences mellate gharbi Shahrekord Chahar-Mahal-va-Bakhtiari Iran (Islamic Republic of)